background: some recent studies reported human epidermal growth factor receptor (her-2/neu) as a marker that can be used in immunological studies of colorectal carcinoma for predicting the prognosis and the treatment. therefore, we aimed to investigate the frequency of her-2 expression in patients with colorectal cancer, and explore the relationship between clinicopathological prognostic factor...

ABSTRSCT: The advent of human epidermal growth factor receptor-2 (HER2) Status and biomarker testing has modified the treatment and prognosis of gastric, breast and colorectal cancer. Epidermal growth factor receptor and HER-2 family maneuvers a key role in the exploitation of gastric cancer by detecting the epidermis express in gastric cancer tissue and to investigate serum and tissue HER2. Ta...

Address correspondence to: Emmanuel Agosto-Arroyo, MD, Department of Pathology and Laboratory Medicine, PO Box 365067, San Juan PR 00936. Email: [email protected] Objective: Routine Progesterone and Estrogen hormone receptor proteins and human epidermal growth factor receptor 2 (HER-2) analysis on invasive breast carcinomas provide therapeutic and prognostic values, revealing significant ...

Targeted drugs therapies that block the molecular pathways involved in the development and progression of gastro-intestinal (GI) cancers have recently gained considerable attention. In addition to agents targeting vascular endothelial growth factor (VEGF), epidermal growth factor receptor, the multi-kinase inhibitor, and regorafenib have also become available for the treatment of metastatic col...

Purpose: We investigated the antitumor activity of the combination of two different humanized monoclonal human epidermal growth factor receptor (HER) 2 antibodies, pertuzumab and trastuzumab,

Purpose: We investigated the antitumor activity of the combination of two different humanized monoclonal human epidermal growth factor receptor (HER) 2 antibodies, pertuzumab and trastuzumab,

Citrus maxima or pomelo is a plant that has potential as an anticancer because it contains flavonoids. One of the targets breast receptors HER-2 protein. This research aims to determine activity, toxicity compound, and prediction physicochemical properties flavonoids contained in through silico approach. Flavonoid compounds were screened using SwissADME with Lipinski's rule five, Torsion, TPSA,...