background: as a drug target and an antigenic agent, hiv-1 protease (hiv-1 pr) is at the center of attention for designing anti-aids inhibitors and diagnostic tests. in previous studies, the production of the recombinant protease has been faced with several difficulties; therefore, the aims of this study were the easy production, purification of the soluble form of protease in e. coli and inves...

background and aims: genotyping assay has been accepted as a guidance in the therapeutic management of human immunodeficiency virus 1 (hiv-1). but, it is not commonly used in our country due to its high running cost. the aim of this study is evaluate an in-house genotyping resistance test (grt) for hiv-1. methods: hiv-1 rna of 20 samples were extracted from plasma and rt nested- pcr was perform...

introduction: nowadays, hiv is mostly spreading in asian countries. one of the important routes for hiv transmission in these countries is the vertical route which infects 35% to 45% of newborns. mother’s education, drug prophylaxis and cesarean section, accompanied by banning breastfeeding will decrease this rate to 2%. therefore, mothers’ knowledge about prevention of mother to child transmis...

objective dot blot (db) assay provides highly specific results, but usually not reliable for quantification of antibody production. the need for a more objective db assay to provide a better definition of the immune status, against hiv antigens, promoted this study to be done to develop a quantitative db assay. material and methods dot blot (db) strips for antibodies directed to human immunodef...

human immunodeficiency virus (hiv) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. cardiomyopathy (cmp) is one of these disturbances that have been associated with high rates of morbidity and mortality. in this review article, several aspects of potential relationships between hiv infection and cardiomyopathy development have been...

Background and Objectives: HIV infected patients are at risk for vaccine-preventable infections such as tetanus and diphtheria (Td). In these patients, these antibodies tend to decline faster. Due to the limited data, this study assessed the seroprevalence of tetanus and diphtheria antibodies in HIV infected patients in Tehran, Iran. Materials and Methods: This case-control study was carried o...

  Background and Objective: Anemia is a common manifestation of human immunodeficiency virus (HIV) infection, occurring in approximately 30% of patients with asymptomatic infection and in as many as 75% to 80% of those with AIDS. Anemia has been associated with decreased quality of life and decreased survival. In this study we aimed to determine the prevalence and related factors of anemia in ...

AIDS (Acquired Immunodeficiency Syndrome) is a condition caused by the Human Virus (HIV). HIV virus that attacks immune system and weakens body's ability to fight off infections diseases. Approximately 37.6 million people (about twice population of New York) worldwide are infected with human immunodeficiency (HIV) according data from Joint United Nations Program on HIV-AIDS.

Background: Oral lesions are among the earliest clinical manifestations of human immunodeficiency (HIV) infection and are important in early diagnosis and for monitoring the progression to acquired immunodeficiency syndrome (AIDS). The purpose of this study was to determine the prevalence of oral lesions and their relationship with a number of factors in HIV/AIDS patients attending an HIV cente...