Phenolic compounds are industrial chemicals widely used in the manufacture of products. Most of them are generated artificially and are found in the wastewaters from chemical plants, exhaust gases from incinerators, the side stream smoke from cigarettes. They are easily adsorbed in humans, regardless of their form. High levels of phenols have been shown to have detrimental effects on animal hea...

A hybrid nanostructure based on reduced graphene oxide and ZnO has been obtained for the detection of volatile organic compounds. The sensing properties of the hybrid structure have been studied for different concentrations of ethanol and acetone. The response of the hybrid material is significantly higher compared to pristine ZnO nanostructures. The obtained results have shown that the nanohyb...

Thermal and antimicrobial properties of hybrid synthesized compounds were evaluated in thepresent study. Hybrid structures were synthesized via two main organic and inorganic components,namely: 2-Mercaptobenzothiazole (MBT) and sodium Montmorillonite clay (Na+-MMT). The synthesis process took place in a direct reaction, intercalation; and the resultingmaterial was characterized. Results of scan...

Twenty-four new hybrid analogues (15-38) containing 7-chloro-4-aminoquinoline and 2-pyrazoline N-heterocyclic fragments were synthesized. Twelve of the new compounds were evaluated against 58 human cancer cell lines by the U.S. National Cancer Institute (NCI). Compounds 25, 30, 31, 36, and 37 showed significant cytostatic activity, with the most outstanding GI50 values ranging from 0.05 to 0.95...

Nitric oxide (NO) plays important roles in cardiovascular regulation, nerve transmission delivery and immune responses. In the last semicenturry, it has been proved that though low concentration of NO is tumor-promoting, high concentration of NO could exhibit multiple antitumor effects, which led to the research and development of kinds of NO donors and NO donor hybrid compounds as antitumor ag...

Organic-inorganic hybrid compounds based on lead halide units of the formula (CH3NH3)2(CH3C6H4CH2NH3)2Pb3(BrxY1−x)10 (Y = Cl, I) were prepared from melts, and their optical absorption as well as photoluminescence spectra, before and after grinding the compounds, were investigated. The luminescence of the materials after grinding is strong and is observed with naked eye. By changing the mole fra...

in this research, we report the results of dft calculations using xc-hybrid functional, b3lyp and employ nbo interpretation to investigate the stereoelectronic effects. electrostatic and steric impacts on the conformational properties of 1,2-difluorodiazene (1), 1,2-dichlorodiazene (2) and 1,2-dibromodiazene (3) are also studied. factors determining the thermodynamically stable molecular struct...

In a search for effective compounds against both the blood- and liver-stages of infection by malaria parasites with the ability to block the transmission of the disease to mosquito vectors, a series of hybrid compounds combining either a 1,2,4-trioxane or 1,2,4,5-tetraoxane and 8-aminoquinoline moieties were synthesized and screened for their antimalarial activity. These hybrid compounds showed...

Peptide nucleic acids (PNA) mimic DNA and RNA by forming complementary duplex structures following Watson-Crick base pairing. A set of reporter compounds that bind to DNA by intercalation are known, but these compounds do not intercalate in PNA/DNA hybrid duplexes. Analysis of the hybrid PNA duplexes requires development of reporter compounds that probe their chemical and physical properties. W...

RNA:DNA hybrids are important structures that are transiently formed in the course of many vital biological processes, including DNA replication,1 telomere replication by telomerase,2 and the replication of HIV (and other retroviruses) by reverse transcription.1 The rate of replication is often elevated in malignant cells, making selective inhibition of replication a fundamental goal in cancer ...