INTRODUCTION Gestational trophoblastic diseases (GTD) are a spectrum of tumors with a various of biological behavior and potential for metastases. It consists of hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor. Choriocarcinoma presents a very aggressive tumor with high malignant potential. CASE REPORT We presented the two cases of choriocarcinoma with br...

A 31-year-old lady presented with abnormal vaginal bleeding during her first trimester of pregnancy. Based on the ultrasound findings and decreasing hCG trend (from 1040 mIU/mL to 759 mIU/mL), a diagnosis missed miscarriage was made. week later, patient heavy bleeding. Ultrasound showed classic snowstorm appearance suggestive complete hydatidiform mole. The serum level however, 357 mIU/mL. In c...

BACKGROUND Differential diagnosis between complete hydatidiform mole, partial hydatidiform mole and hydropic abortion, known as hydropic placentas is still a challenge for pathologists but it is very important for patient management. OBJECTIVE We analyzed the nuclear DNA content of various types of hydropic placentas by flowcytometry. MATERIALS AND METHODS DNA ploidy analysis was performed ...

The incidence of mole pregnancy appears to be higher in Iran than in Europe or North America. This gave us an opportunity to study a number of biochemical measurements related to the thyroid. In 14 patients with hydatiform mole, the T3 resin uptake, serum thyroxine (T4), ETR, T3 RIA, human serum TSH (hTSH) and serum human Chorinic gonadotropin (hCG) were measured. Of the 14 patients 6 sho...

Hydatiform mole belongs to a group of diseases classified as gestational trophoblastic disease,that results from an impaired fertilization.Moles have been divided into complete or partial moles on the basis distinctive histopathological features and genetic abnormalities.Partial molar pregnancy with coexisting fetus is rare complication incidence 0.005%-0.01% all pregnancies.It usually derives ...

A specific and highly sensitive radioimmunoassay for determination of pregnancy-associated plasma protein A in human serum is described. The minimum detection limit for this protein was 2.9 micrograms/L. The within- and between-assay coefficients of variation were 4.0 and 4.5%, respectively. The circulating protein was detected within 32 days of conception in eight normal pregnancies and within...

background: differential diagnosis between complete hydatidiform mole, partial hydatidiform mole and hydropic abortion, known as hydropic placentas is still a challenge for pathologists but it is very important for patient management. objective: we analyzed the nuclear dna content of various types of hydropic placentas by flowcytometry. materials and methods: dna ploidy analysis was performed i...

OBJECTIVE To evaluate the contribution of referent pathologists (RPs) to the quality of diagnosis of trophoblastic diseases and to study the level of diagnostic agreement between the initial pathologists and the RPs. METHODS This observational retrospective study was carried between 1 November 1999 and 11 January 2011 using the database of the French Trophoblastic Disease Reference Centre in ...