Introduction of newer hypotensive agents from time to time is a pointer to the unsolved problemof the treatment of hypertension. Severe hypertension (grades III and IV) is still a challengingproblem for the physician. In the therapeutic armamentarium of hypertension somenew drugs have disappeared faster than they were introduced because of their serious hazardsor limitations. A clinician has, t...

Obesity is a risk factor for stroke, but the determinants of increased stroke risk in obesity are unknown. We have previously reported that obese Zucker rats (OZRs) have a worse stroke outcome and display evidence of remodeling of the middle cerebral artery (MCA), in parallel with hypertension, compared with lean controls. This study tested the hypothesis that hypertension is an essential deter...

This study describes 3 dogs that experienced recurrent refractory CHF after receiving furosemide. Furosemide was then discontinued and torsemide initiated. Furosemide Versus Torsemide. A study of 7 dogs with clinically stable CHF demonstrated that replacement of furosemide with torsemide was both safe and . Torasemide is a new loop diuretic that combines the effects of furosemide and spironolac...

In traditional system of medicine S. xanthocarpum is used treating difficulty in urination and renal calculus. The objective of the present study was to scientifically evaluate diuretic potential of S. xanthocarpum. The study was divided into two phases of evaluation (acute and sub-acute) with administration of aqueous extract of S. xanthocarpum roots. The animals were treated with either aqueo...