This paper compares the morphologies of films of conjugated polymers in which the backbone (main chain) and pendant groups are varied between ionic/hydrophilic and aliphatic/hydrophobic. We observe that conjugated polymers in which the pendant groups and backbone are matched, either ionic-ionic or hydrophobic-hydrophobic, form smooth, structured, homogeneous films from water (ionic) or tetrahyd...

Percolation theory has been applied in order to study the existence of critical points as well as the possibility to find a "combined percolation threshold" for ternary hydrophilic matrices prepared with HPMC, NaCMC, and theophylline. For this purpose, different batches of ternary as well as binary hydrophilic matrices have been prepared. Critical points have been found for binary hydrophilic m...

Hydrophilic polymers were attached to lysozyme by a combination of grafting-to and grafting-from approaches using RAFT polymerization. A hydrophilic oligomer was synthesized, and attached to the protein. The protein-oligomer hybrid contained the RAFT end group, enabling chain extension in solution. Lysozyme maintained activity throughout this process.

The design and synthesis of a family of cationic, pH-sensitive poly(amidoamine)s are reported. Acetal or ketal linkages were incorporated into the backbone of the polymers to provide for degradation into low molecular weight hydrophilic compounds upon lowering of the pH. All of the polymers demonstrated a pHdependent degradation profile with a very significant increase in hydrolysis rate as the...

the interaction of drugs and polymers used to incorporate in or surface modify/coat the liposomes can affect the phase transition, fluidity and other physical properties as well as in vivo fate of vesicles. in this study, differential scanning calorimetry (dsc) was used to investigate changes in the temperature and the enthalpy of phase transition of liposomes of various electrical charges foll...

Understanding the role of surface decoration of nanoparticles in protein adsorption and cellular uptake is of great importance in biomedicine. Here, by using dissipative particle dynamics simulations, we take two typical coating polymers (i.e., hydrophilic and zwitterionic polymers) as an example, and systematically investigate their effect on cellular delivery of hydrophobic and charged nanopa...