Aromatische Seitenketten sind wichtige Indikatoren für die Plastizität von Proteinen und bilden oft entscheidende Kontakte bei Protein-Protein-Wechselwirkungen. Wir untersuchten aromatische Reste in den beiden strukturell homologen cross-β Amyloidfibrillen HET-s HELLF mit Hilfe eines spezifischen Ansatzes zur Isotopenmarkierung Festkörper NMR Drehung am magischen Winkel. Das dynamische Verhalte...

Vesicles formed in water by synthetic macro-amphiphiles have attracted much attention as nanocontainers having properties that extend the physical and chemical limits of liposomes. We sought to develop ABA block copolymeric amphiphiles that self-assemble into unilamellar vesicles that can be further oxidatively destabilized. We selected poly(ethylene glycol) (PEG) as the hydrophilic A blocks, o...

We performed large-scale molecular-dynamics simulation of nanoscale hydrophobic interaction manifested by the formation of nanobubble between nanometer-sized hydrophobic clusters at constrained equilibrium. Particular attention is placed on the tendency of formation and stability of nanobubbles in between model nanoassemblies which are composed of hydrophobic clusters (or patches) embedded in a...

A suitable reaction system, and proper conditions were designed to produce desirable polyurethane base thickener with a calculated number average molecular weight. Initially an ethoxylated urethane prepolymer was synthesized by reaction of a polyethylene glycol (M„=6000) and dicyclohexylmethane diisocyanate using the step growth polymerization technique. Modification was carried out by reaction...

A ggregationsfähigkeit verloren, und zwar im Falle von A lanin stärker als von Valin. W ichtig fü r die Frage der Tem peratursensitivität, d. h. den V erlust der Fähigkeit zu geordneter A ggre­ gation der P roteinuntereinheiten unter bestimmten Bedingungen, ist die Kom bination einer bestimmten A m inosäure m it einer bestimmten Position inner­ halb der P roteinkette. Es ist für diese Frage neb...

This paper combines new experimental data for electrokinetic characterization of hydrophobic polymers with a detailed discussion of the putative origins of charge at water-hydrophobe interfaces. Complexities in determining the origin of charge are discussed in the context of design and modeling challenges for electrokinetic actuation in hydrophobic microfluidic devices with aqueous working flui...

A number of ethoxylated nonionic surfactants differing in hydrophobe branching and chain lengths have been evaluated for environmental responses. Screening biodegradation tests show those non-ionics having more than one methyl group per hy-drophobe degrade considerably slower than those having less extensive branching. Continuous flow-through activated sludge tests, simulating actual waste trea...