conclusions considering the strong historical background about the therapeutic potential of the genus hypericum and the considerable cytotoxic and apoptosis induction ability of hypericum scabrum, this species is suggested for future biological studies. results di-chloromethane fraction demonstrated ic50 values of 25.72 μg/ml and 24.73 μg/ml against ht-29 and hepg-2 cell lines, respectively and...

OBJECTIVES Hypericum spp. (H.) has been used in traditional medicine for their sedative effect for many years. In spite of many works on this genus, little is known about H. scabrum. In this work antidepressant and its protective effect against hypoxia-induced lethality were evaluated. MATERIALS AND METHODS Antidepressant and its protective effects against hypoxia-induced lethality were evalu...

The overall purpose of this study was to investigate Neurostan Saint John’s Wort (SJW) on the disposition of fexofinadine in the isolated perfused rat liver. SpragueDawley (SD) rats (n = 16) randomized into 3 groups, including: control, low dose (Hypericum, one type of neutostan) and high dose group. Each animal among these groups was pre-treated with either vehicle (ethanol in Milli Q water at...

Next generation sequencing technology rapidly developed research applications in the field of plant functional genomics. Several Hypericum spp. with an aim to generate and enhance gene annotations especially for genes coding the enzymes supposedly included in biosynthesis of valuable bioactive compounds were analyzed. The first de novo transcriptome profiling of Hypericum annulatum Moris, H. to...

Model studies of the influence lectin-containing extracts medicinal plants St. John's wort (Hypericum perforatum L.), common yarrow (Achillea millefolium marigold (Calendula officinalis L.) and dwarf evergreen (Helichrysum arenarium (L.) Moench.) on growth development wheat, oat, barley rye at beginning their ontogenesis. They testify to specificity action in relation model objects, which is pr...

BACKGROUND Mastitis reduces milk yield and alters milk composition. Antibiotics are widely used in the treatment of the disease. However, this widespread use of antibiotics causes both antibiotic residues in milks and antibiotic resistance developed in bacteria. Today's researches are focused on discovering and using new antibiotics against bacteria. OBJECTIVE The aim of this work was to disc...

background & aim: st john's wort (hypericum perforatum l.) contains hypericin and hyperforin as the main components of the extract that binds with gaba and sigma opioid receptors. this herb has many pharmacological effects, including analgesic, sedative, soothing, antispasmodic, anticonvulsant, anti-depressant, and anti-bacteria. in this study examined the effect of two concentrations of hy...

BACKGROUND Extracts of Hypericum perforatum (St John's wort) are widely used to treat depression. Evidence for its efficacy has been criticised on methodological grounds. AIMS To update evidence from randomised trials regarding the effectiveness of Hypericum extracts. METHODS We performed a systematic review and meta-analysis of 37 double-blind randomised controlled trials that compared cli...