Anorectal melanomas are rare tumors that occur more frequently with advancing age and peak in the sixth and seventh decades (Felz et al., 2001). Surgery is considered to be optimal therapy; however, chemotherapy and immunotherapy have been shown to be effective in a small number of patients.

A punch biopsy of the axillary region was performed for histopathological study, staining with hematoxylin-eosin (Figure 2), periodic acid-Schiff (PAS), and Congo red. The histological findings included papillomatosis, orthokeratotic hyperkeratosis and epidermal acanthosis, focal atrophy of the granular layer, and mild hyperpigmentation of the basal layer of the epidermis. There was a moderate ...

Background: Toxic epidermal necrolysis (TEN) is an uncommon but potentially fatal condition. TEN distinguished by apoptosis of keratinocytes, which results in erosion the mucous membrane and detachment. Case: A man, 20-year-old, came to hospital with skin sore blisters almost over his body, accompanied swollen eyes, on lips genital. Dermatological examination regio trunk showed erythematous hyp...

INTRODUCTION Dermatosis neglecta is an often misdiagnosed and under-diagnosed condition. In dermatosis neglecta, a progressive accumulation of sebum, sweat, keratin and other dirt and debris, occurs due to inadequate local hygiene resulting in a localized hyperpigmented patch or a verrucous plaque. Vigorous rubbing with alcohol-soaked gauze or soap and water results in a complete resolution of ...

We present the case of a 2-year-old boy with multiple Spitz nevi clustered on a hyperpigmented macule that obeyed a quadrant distribution. Multiple Spitz nevi are rare and can be disseminated or clustered. A third of the cases of agminated lesions appear on hyperpigmented macules.

Becker's nevus is a relatively common cutaneous hamartoma, but is often overlooked or misdiagnosed. This nevus usually begins during the second decade of life as a circumscribed, hyperpigmented patch with irregular outline that gradually enlarges with associated hypertrichosis, developing several years later. The purpose of this study was to determine the prevalence of lesional hypertrichosis a...