BACKGROUND Radiofrequency ablation (RFA) is a relatively new treatment for hypersplenism. The results of a randomized clinical trial comparing RFA and splenectomy with 5 years of follow-up are reported. METHODS Fifty-seven patients with hypersplenism due to liver cirrhosis were assigned randomly (in a 1 : 2 ratio) to splenectomy (19 patients) or RFA (38). The RFA group was subdivided accordin...

The aim of this study was to investigate the interrelation between splenic siderotic nodules, hypersplenism and liver function in patients with liver cirrhosis. The splenic enhanced susceptibility-weighted angiography (ESWAN) and conventional magnetic resonance images of 33 patients with liver cirrhosis were retrospectively studied and the ESWAN images were graded. The distribution and prevalen...

BACKGROUND AND OBJECTIVES Patients undergoing synchronous open splenectomy and hepatectomy (OSH) for concurrent hepatocellular carcinoma (HCC) and hypersplenism usually have major surgical trauma caused by the long abdominal incision. Surgical procedures that contribute to rapid recovery with the least possible impairment are desired by both surgeons and patients. The objective of this study wa...

Splenomegaly and pancytopenia are common in Wilson's disease (WD) and splenectomy is one of the conventional treatments for splenomegaly and the associated pancytopenia. However, splenectomy remained controversial for hypersplenism in WD as it was reported that splenectomy leaded to serious emotional and neurological deterioration in WD patients with hypersplenism. In the current study, we pres...

Background: The aim of this study was to evaluate the efficacy of splenic irradiation in relieving symptoms and hematological disorders that accompanying hypersplenism from congestive splenomegaly in cirrhotic patients secondary to chronic viral hepatitis and if the presence of platelet-associated immunoglobulins (AIgs ) can affect the degree of thrombocytopenic recovery in these patients.Patie...

I HE SYNDROME of hypersplenism is characterized by splenomegaly, selective or total blood cytopenias, normal or hyperplastic bone marrow, and disappearance of the cytopenias after splenectomy. The mechanism of the various forms of hypersplenism ( splenic thrombocytopenia, spenic anemia, splenic neutropenia, splenic pancytopenia ) is still under discussion. Clinical and experimental evidence has...

Background and Aim: Hypersplenism is a complication of portal hypertension commonly encountered in gastroenterology practice. Partial splenic artery embolization (PSAE) one the attractive treatment modalities, which less invasive than splenectomy for managing hypersplenism. We aimed to evaluate safety efficacy PSAE treating hypersplenism hypertension. Methods: analyzed prospectively collected d...

A 16 year old girl with Type 1 Gaucher's disease presented with massive splenomegaly, hypersplenism and abdominal discomfort. Traditionally hypersplenism has been treated with splenectomy, but this results in a high incidence of overwhelming sepsis and accelerated sphingolipid deposition in both liver and bone. A 90% partial splenectomy was therefore performed leaving a fully vascularized infer...