The aim of this study was to evaluate whether sustained hypertensives with high clinic blood pressure, despite multiple drug treatment, show a true resistant hypertension or a ‘‘white-coat effect,’’ and whether the pretreatment white-coat effect is maintained despite pharmacological therapy. The occurrence of resistant hypertension was determined in 250 consecutive essential hypertensives who h...

BACKGROUND & OBJECTIVE Secretory phospholipase A(2) (sPLA(2)) and oxidized low density lipoprotein (oxLDL) are considered as oxidative and inflammatory markers. The effects of oxLDL have been shown to be inhibited by paraoxonase (PON1). This study was undertaken to investigate the relationship between oxidative and inflammatory markers in hypertensive patients with or without antihypertensive d...

The interaction of three different Na+ transport systems (Na+-K+ pump, Na+-K+ cotransport and Na+-Li+ countertransport), with internal Na+ and the passive Na+ leaks, were measured in erythrocytes from 72 Spanish, essential hypertensive patients and 30 normotensive controls. According to the observed abnormalities in Na+ transport pathways, 93.1% of the patients were classified into the followin...

The functional and morphologic characteristics of isolated subcutaneous resistance vessels (about 170 micron i.d.) from 15 untreated subjects with essential hypertension and 15 matched controls were examined. The vessels from the hypertensives had a 29% increase in the media-thickness-to-lumen-diameter ratio. The maximal force development to noradrenaline (NA) expressed as active pressure (an e...

The critical opening pressure (COP) of digital vessels after digital nerve block and the change in COP caused by angiotensin at 4 mug/kilo per min intravenously after the block were compared in 9 normotensive subjects, 8 patients with essential hypertension and 7 patients with various lands of renal hypertension. The COP after nerve block was less than 20 mm Hg in the normotensives and in 6 ren...

Conscious normotensive and two-kidney, one clip Goldblatt hypertensive dogs were studied to determine the influence of the sympathetic and renin-angiotensin systems on the blood pressure and renal blood flow. Renal blood flow was monitored in a single kidney of the normotensive dogs and in the contralateral kidney of the hypertensive dogs. Saralasin was infused intravenously (i.v.) at 1 microgr...

BACKGROUND Biglycan (BGN), an extracellular matrix proteoglycan, has been shown to convey pro-inflammatory signals. In the present study we investigated BGN expression and its correlation with plasma levels of inflammatory markers in hypertensive subjects with or without alteration of carotid intima media thickness (IMT). METHODS We evaluated 123 untreated essential hypertensives with no addi...

Despite the importance of achieving cardiometabolic goals beyond blood pressure, in the health of hypertensives, no comprehensive assessment of these characteristics has been performed in whole countries. We studied in 2008-2010 a total of 11 957 individuals representative of the Spanish population aged≥18 years. Information on cardiometabolic characteristics was collected at the participants' ...

BACKGROUND In developing countries, gender-based treatment disparities in cardiovascular preventive therapy have received little attention. AIMS To evaluate the gender-based differences in cardiovascular disease risk profile, drug prescribing pattern, and blood pressure (BP) and glycemic control rates in diabetic hypertensives treated at primary care setting in Bahrain. SETTINGS AND DESIGN ...

Isometric exercise causes a substantial rise in BP in normotensive and untreated hypertensives. The authors studied the isometric hand-grip test in 5 groups of treated hypertensives, namely beta-blockers, beta-blockers + diuretics, beta-blockers + diuretics + vasodilators, alpha-methyldopa alone and labetalol. All groups showed a substantial rise in both systolic and diastolic BP, and the incre...