BACKGROUND/AIMS Long non-coding RNAs (lncRNAs) are thought to play crucial roles in human diseases. However, the function of lncRNAs in hypertrophic scar formation remains poorly understood. METHODS In this study, we investigated the expression of lncRNA8975-1 in hypertrophic scar tissues and fibroblasts by quantitative reverse transcription PCR (qRT-PCR). To investigate its function, overexp...

The scanning electronmicroscopic appearances of hypertrophic and keloid scar before and after treatment, mature scar and normal skin have been investigated. There is a graduation of features such as collagen orientation and fibre size which accompanies the clinical maturation from the active hypertrophic state into mature scar, a process which is hastened but not materially altered by treatment...

Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated in hypertrophic scar and normal deep dermal fibroblasts. It was hypothesized that microRNAs in these fibroblasts downregulate decorin and bloc...

Keloids are benign skin tumours occurring during wound healing in genetically predisposed patients. They are characterized by an abnormal deposition of extracellular matrix components, particularly collagen. There is uncertain evidence that transforming growth factor-beta (TGFss) is involved in keloid formation. Therefore we investigated the expression of TGFss1, 2 and 3 and their receptors in ...

A recent study reported that Botulinum toxin type A (BTXA) could inhibit the growth of hypertrophic scars and improve their appearance. However, the mechanism of BTXA's action on hypertrophic scars is still unknown. Some in vitro studies had shown BTXA could alleviate hypertrophic scars by acting on the biological behavior of fibroblasts, but there are few in vivo experiments, especially animal...

Although hypertrophic scarring commonly occurs following burns, many aspects such as incidence of and optimal treatment for scar hypertrophy remain unclear. This review will focus on hypertrophic scar formation after burn in particular, exploring multiple treatment options and describing their properties as well as effectiveness. To evaluate treatment efficacy and scar development, clinical sca...

Hypertrophic scars exhibit a higher prevalence within groups with darker skin tones. The Vancouver Scar Scale, patient and observer scar evaluation scale, high resolution ultrasound, Modified Scales, ultra-high frequency tonometry, multiphoton microscopy laser Doppler imaging are considered to be optimal tools for measurement of scar. therapeutic modalities employed the hypertrophic management ...

The hypertrophic scar, a consequence of deep surface 1nJury, is peculiar to humankind. Subcutaneous implants of these tissues in nude mice provide a quasi animal model for experimental use. An efficacious treatment to promote acceleration of maturation of the hypertrophic scar is controlled topical pressure produced by flexible dacron fabric wraps. Implants in the nude mouse provide a model for...

This study aims at investigating the efficiency of bimodal spectroscopy in detection of hypertrophic scar tissue on a preclinical model. Fluorescence and Diffuse Reflectance spectra were collected from 55 scars deliberately created on ears of 20 rabbits, amongst which some received tacrolimus injection to provide non-hypertrophic scar tissue. The spectroscopic data measured on hypertrophic and ...

Introduction: Keloid and hypertrophic scar are pathological scars resulting from excessive accumulation of collagen in wound healing process. Data about profiles keloid rarely found Indonesia. Therefore, it is necessary to conduct research related scar. This study aimed provide valuable data for further research.Methods: was descriptive retrospective evaluating 105 patients treated 2014 2017 us...