BONE lesions have been described in animals given large doses of vitamin A. The bones are reduced in thickness and fractures are frequent (Moore, 1957). Much of this work has been done on the rat (Moore and Wang, 1945; Wolbach, 1947; Thompson and Pitt, 1960), but lesions have been described in other species including guinea-pigs (Wolbach, 1947), calves (Grey, Nielsen, Rousseau, Calhoun and Eato...

Received August 30, 2007 Abstract Vitamin supplementation is a frequent phenomenon in Hong Kong children for various reasons. Vitamin A is amongst the most frequently used vitamin presented in various 'fish oil' supplements, and its toxicity is being widely reported in literature. Hepatopulmonary syndrome is a triad of chronic liver disease; increased alveolar-arterial oxygen gradient; and evid...

Toxic effects of administering large doses of vitamin A have been known for a long time to occur in human beings as well as in laboratory animals (Josephs, 1944; Knudson & Rothman, 1953). Polar bear liver is an unusually potent source of vitamin A and is toxic as a food even for Eskimo's dogs (Rodahl & Moore, 1943). I n hypervitaminosis A basal metabolism is lowered (Sadhu & Brody, 1947) and li...

In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...

1. The total lipid, phospholipid, total and free fatty acid, free and esterified cholesterol contents of the long bones of normal, hypervitaminotic A, D and A plus D rats were determined. 2. Toxic amounts of vitamin A decreased the total fatty content, whereas toxic amounts of vitamin D increased triglycerides, esterified cholesterol and in particular the phospholipids of bone. 3. An interactio...