Current literature shows an association of diabetes and secondary complications with chronic inflammation. Evidence of these immunological changes include altered levels of cytokines and chemokines, changes in the numbers and activation states of various leukocyte populations, apoptosis, and fibrosis during diabetes. Therefore, treatment of diabetes and its complications may include pharmacolog...

BACKGROUND Diabetes is a serious chronic metabolic disorder. Trichosanthes kirilowii Maxim. (TK) is traditionally used for the treatment of diabetes in traditional Chinese medicine (TCM). However, the clinical application of TK on diabetic patients and the hypoglycemic efficacies of TK are still unclear. METHODS A retrospective cohort study was conducted to analyze the usage of Chinese herbs ...

Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-induced diabetic rats (120 mg/kg, i.p.) at two dose levels, viz., 100 and 200 mg/kg. The ethanol e...

Administration of bio-tea (1.71 ml/kg) to normal albino mice caused hypoglycemia after 30 min which reached to maximum after 2 hr with a significant decrease in blood sugar level (BSL) and became normal beyond 8 hr. In alloxan-induced diabetic albino mice, repeated treatments of bio-tea for 3 days (five doses) brought about a significant fall in mean BSL. Continuous decrease in BSL was observed...

Plants are the only source of a well established traditional and modern drugs and phytochemicals. Many plant species are known in folk medicine of different cultures to be used for their hypoglycemic properties and therefore used for treatment of diabetes. The evaluation of these plants and of their active natural principles is logic way of searching for new drugs to treat this disease. The pre...

This research aims to investigate the hypoglycemic activity of methanolic extract of Tectona grandis root in alloxan induced diabetic albino rats. A comparison was made between the action of Tectona grandis methanolic extract and a known antidiabetic drug glibenclamide (0.5mg/kg p.o).The methanolic extract of Tectona grandis linn. root was administered orally at different doses to normal rats. ...

Gynura medica leaf extract contains significant amounts of flavonols and phenolic acids and exhibits powerful hypoglycemic activity against diabetic rats in vivo. However, the hypoglycemic active constituents that exist in the plant have not been fully elaborated. The purpose of this study is to isolate and elaborate the hypoglycemic activity compounds against inhibition the yeast α-glucosidase...