background & aim: solenostemon monostachyus has remain invincible in ibibio ethnomedicine for the management of numerous ailment including diabetes mellitus. many of these ethnomedicinal claims are yet to be pharmacologically verified. the purpose of this study therefore was to subject the extract/fractions of solenostemon monostachyus used in folkloric management of diabetes to scientific ...

The general lipid-lowering action of the N-substituted phthalimide derivatives reported herein, as well as the activity of potassium phthalimide, implicates the phthalimide moiety as possessing hypolipidemic activity in rodents. Compounds containing substituents with chain lengths of four carbon or oxygen atoms showed the best hypolipidemic activity in the series tested. Tests involving 1-N-pht...

This study was designed in order to correlate the flavonoid and lipoidal matters content of Spinach roots and flowers to their hypolipidemic potential. The total flavonoid content was measured via complexation with aluminum chloride while determination of fatty acids methyl esters and unsaponifiable matters contents in both organs was performed using GC/MS. In an in vitro study, the crude etha...

Resveratrol, a stilbenoid antioxidant found in grapes, wine, peanuts and other berries, has been reported to have hypolipidemic properties. We investigated whether resveratrol and its three analogues (pterostilbene, piceatannol, and resveratrol trimethyl ether) would activate the peroxisome proliferator-activated receptor alpha (PPARalpha) isoform. This nuclear receptor is proposed to mediate t...

This study was designed in order to correlate the flavonoid and lipoidal matters content of Spinach roots and flowers to their hypolipidemic potential. The total flavonoid content was measured via complexation with aluminum chloride while determination of fatty acids methyl esters and unsaponifiable matters contents in both organs was performed using GC/MS. In an in vitro study, the crude etha...

Benzodioxane represents a series of synthetic and natural compounds of considerable medicinal importance. Compounds containing dioxane ring systems exhibited different biological activities such as antihepatotoxic, -adrenergic blocking agent, neuroleptic, anti-inflammatory, hypolipidemic and D 2 antagonist/5-HT 1A partial agonist activity. The literature concerning chemistry of benzodioxanes c...