VOLUME 99, JUNE 2017 E1 WWW.CUTIS.COM To the Editor: Melanoma-associated hypopigmentation frequently has been reported during the disease course and can include different characteristics such as regression of the primary melanoma and/or its metastases as well as common vitiligolike hypopigmentation at sites distant from the melanoma.1,2 Among patients who present with hypopigmentation, the most...

OBJECTIVE Advances in melanocyte culture techniques have not yet led to reliable clinical methods for treating hypopigmentation disorders. We hypothesized that melanocytes harvested from plucked hair follicles may provide a renewable source of melanocytes for the treatment of hypopigmentation. METHODS Hairs with attached cells from the follicles were plucked from Yucatan pigs and implanted in...

A 52-year-old Latino male without significant medical history reported 1 month of left lateral elbow pain that worsened with repetitive movement of his wrist. He was diagnosed with lateral epicondylitis (tennis elbow) and initially treated with non-steroidal anti-inflammatory drugs and rest. Due to lack of improvement, he received a local triamcinolone injection with symptoms relieved after a f...

Melanocytes, the pigment-producing cells, arise from multipotent neural crest (NC) cells during embryogenesis. Many genes required for melanocyte development were identified using mouse pigmentation mutants. The variable spotting mouse pigmentation mutant arose spontaneously at the Jackson Laboratory. We identified a G-to-A nucleotide transition in exon 3 of the Ets1 gene in variable spotting, ...

BACKGROUND Congenital melanocytic nevi (CMN) are present at birth. It is well known that the presence of large-sized congenital nevus in early life could predict a major risk of developing melanoma. OBJECTIVE To investigate the clinical and dermoscopic features of the CMN, to search for and highlight any differences between small-sized, medium-sized, large-sized CMN. METHODS A nonrandomized...

BACKGROUND Sorafenib can be considered as the effective option of treatment in patients with metastatic radioiodine refractory differentiated thyroid cancers. The cutaneous manifestations of Sorafenib include rash, desquamation, hand foot skin reactions, pruritus, alopecia and erythema. We report the first case of hypopigmentation related to sorafenib therapy. CASE PRESENTATION We report the ...

Skin pigmentation is a natural phenomenon that plays an important part in the appearance and biology of all animals, including humans. The process melanogenesis, which results formation pigment melanin within melanocytes, determines skin colour. This controlled by both inherent external factors. Tyrosinase catalyzes essential step melanogenesis; dysfunction tyrosinase leads to reduce synthesis ...

Aims: Pigmentation disorders are one of the main skin problems due to mustard gas exposure in chemically-injured veterans. The aim of this study as part of the Sardasht cohort study was to investigate the association between IL-6 and IL-4 and pigment disorders in chemically-injured veterans exposed to mustard gas. Materials & Methods: In this study, 500 subjects including 372 people expose...