BACKGROUND Some studies have suggested an association between paternal subfertility and hypospadias among their sons, although the association has not been systematically investigated. We therefore compared male reproductive health among a group of fathers of boys with hypospadias and a group of fathers to normal children. METHODS A total of 64 fathers of boys with hypospadias participated; 3...

Introduction : Hypospadias can be defined as an abnormal urethral orifice under surface of the penis with or without chordee and with or without dorsal hood. At a critical time in sexual differentiation of the male fetus, HCG enters fetal plasma from syncytio trophoblast; acts as an LH surrogate and stimulate replication of testicular Ley dig cells and testosterone synthesis to promote male sex...

BACKGROUND An increase in the prevalence of hypospadias has been reported, but the environmental causes remain virtually unknown. OBJECTIVES Our goal was to assess the association between risk of hypospadias and indicators of placental function and endogenous hormone levels, exposure to exogenous hormones, maternal diet during pregnancy, and other environmental factors. METHODS We conducted...

abstract: Hypospadias is one of the most common congenital malformations. Few studies have explored the association of age at time of surgery and the occurrence of complications after hypospadias repair. We undertook this study to determine whether age at hypospadias repair is a risk factor for development of complications. Hypospadias is one of the most common congenital malformations. Few stu...

Hypospadias is one of the most common congenital anomalies that can be treated with surgical reconstruction. The etiology in the majority of cases of hypospadias remains elusive. Androgens are clearly critical for penile development; however, defects in androgen metabolism and/or the androgen receptor explain only a small subset of patients with hypospadias. This paper reviews the present strat...

PURPOSE To review the evolution of the technique of hypospadias repair. METHODS A search of Pubmed, Medline and the Journal of Pediatric Urology was performed, and papers dealing with surgical techniques for hypospadias repair were critally reviewed. Special emphasis was given to papers on the effects in the long term of hypospadias repair on voiding and sexual dysfunction. RESULTS The tech...

Hypospadias is an anomaly of the male urogenital tract which occurs as a result of deficient closure of the urethral groove. Hypospadias is the most commonly seen urogenital anomaly in male neonates, but it is rarely diagnosed during prenatal period. Herein, a severe hypospadias case which was diagnosed by using 2D (two-dimensional) and 3D (three-dimensional) ultrasonography at 28 weeks of preg...

OBJECTIVES To determine the trend of hypospadias incidence in New York State (NYS) by retrospectively evaluating both the incidence and surgical repair rates of hypospadias. Epidemiologic studies in the United States and Europe have suggested an observable trend in the incidence of hypospadias during the past 30 years. A comparison of the results from these studies, however, revealed inconsiste...

The aim was to retrospectively determine the real incidence of congenital penile curvature in various forms of hypospadias, in order to indicate intraoperative assessment and correction of curvature. We analyzed 842 patients with hypospadias who underwent surgery from 2003 to 2010, classified into two groups. First group was intraoperatively checked for curvature as a routine procedure, while a...

BACKGROUND Hypospadias is a common congenital malformation of the male external genitalia. Most cases have an unknown aetiology, which is probably a mix of monogenic and multifactorial forms, implicating both genes and environmental factors. This review summarizes current knowledge about the aetiology of hypospadias. METHODS Pubmed was used to identify studies on hypospadias aetiology publish...