Heterogeneous network computing enables the development of a single complex application using a distributed network of possibly dissimilar machines. While heterogeneous networks promise cost-eeective compute cycles, almost no software is available to aid in the design and implementation of their applications. In this paper, we couple the Zoom representation, designed to facilitate development o...

Background: Progesterone is an endogenous immunomodulator that suppresses T cell activation during pregnancy. The stimulation of membrane progesterone receptors (mPRs) would seem to be the cause of rapid non-genomic responses in human peripheral T cells, such as an elevation of intracellular calcium ([Ca2+] i) and decreased intracellular pH (pHi). Mifepristoneimmune cells compared with progeste...

Speech delay with an unknown cause is a problem among children. This diagnosis is the last differential diagnosis after observing normal findings in routine hearing tests. The present study was undertaken to determine whether auditory brainstem responses to click stimuli are different between normally developing children and children suffering from delayed speech with unknown causes. In this cr...

I propose that pre-attentive computational mechanisms in primary visual cortex create a saliency map. This map awards higher responses to more salient image locations; these responses are those of conventional V1 cells tuned to input features, such as orientation and color. Hence no separate feature maps, or any subsequent combination of them, is needed to create a saliency map. I use a model t...

Network computing seeks to utilize the aggregate resources of many networked computers to solve a single problem. In so doing it is often possible to obtain supercomputer performance from an inexpensive local area network. The drawback is that network computing is complicated and error prone when done by hand, especially if the computers have diierent operating systems and data formats and are ...

Abstract Plasmacytoid dendritic cells (pDCs) chronically produce type I interferon (IFN-I) in autoimmune diseases, including systemic sclerosis (SSc) and lupus erythematosus (SLE). We report that the IRE1α-XBP1 branch of unfolded protein response (UPR) inhibits IFN-α production by TLR7- or TLR9-activated pDCs. In SSc patients, UPR gene expression was reduced pDCs, which inversely correlated wit...