Apomyoglobin folding proceeds through a molten globule intermediate (low-salt form; I1) that has been characterized by equilibrium (pH 4) and kinetic (pH 6) folding experiments. Of the eight alpha-helices in myoglobin, three (A, G, and H) are structured in I1, while the rest appear to be unfolded. Here we report on the structure and stability of a second intermediate, the trichloroacetate form ...

The goal of this study was to determine the role of prostanoids in a new model of mineralocorticoid-dependent hypertension induced by the subcutaneous infusion of aldosterone (1 micrograms/hr) to normal male Sprague-Dawley rats. This regimen caused a mild and gradual increase in systolic pressure over a period of 4 weeks (113 +/- 1 vs. 137 +/- 3 mm Hg) and was associated with an increase in the...

BACKGROUND Several epidemiological studies have determined the associations between coffee intake level and skin cancer risk; however, the results were not yet conclusive. Herein, we conducted a systematic review and meta-analysis of the cohort and case-control studies for the association between coffee intake level and malignant melanoma (MM) risk. METHODS Studies were identified through sea...

OBJECTIVES To establish a three-dimensional (3D) finite element (FE) model of a maxillary first premolar and to evaluate the stress generated on the tooth (dentine) and on the indirect composite resin restorations by occlusal forces. METHODS An embedded intact maxillary first premolar tooth was sliced serially and scanned digitally parallel to the occlusal surface. The 64 images were assemble...

this study was carried out to determine the optimal irrigation intervals in sugar beet seed production fields and to evaluate the effects of irrigation at different growth stages of sugar beet seed bearing plants (cv. shirin) on seed qualitative and quantitative characteristics. the treatments were four irrigation intervals including a control (i1) (irrigation at three stages; planting, bolting...

sustainable economical production of tea depends on the proper use of water and fertilizer. for this purpose, the role of supplemental irrigation and nitrogen fertilizer on economical production of tea plantations was studied by assessment of yield, production function, water use efficiency, and benefit/cost ratio, and final return in a field experiment at feshalam tea research station in fouma...