Evidence Single-agent comparisons: • Ibuprofen versus acetaminophen versus codeine: RCT1 of 336 children with MSK injuries (54% fractures). -At 60 minutes on a 100-mm pain scale, ibuprofen led to —greater mean reduction (-24 mm) versus acetaminophen (-12 mm) or codeine (-11 mm). —more patients achieving adequate analgesia (< 30 mm) versus acetaminophen (number needed to treat [NNT] = 7) or code...

BACKGROUND Musculoskeletal injuries (MSK-Is) are a common and painful condition among children that remains poorly treated in the emergency department (ED). We aimed to test the efficacy of a combination of an anti-inflammatory drug with an opioid for pain management of MSK-I in children presenting to the ED. METHODS In this randomized, double-blinded, placebo-controlled trial, we enrolled ch...

microencapsulation has become a common technique in the production of controlled release dosage forms. many results have been reported, concerning the use of alginate beads as controlled release drug formulations. alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflam...

In this study, we report the simulation of the ozone disinfection of drinking water in the presence of ibuprofen, its oxidative degradation products, and the acute toxicity analysis by luminescent bacteria bioassay. The results showed that the ibuprofen oxidation followed first-order kinetics. The ultra-performance liquid chromatography quadrupole time-of-flight mass (UPLC/Q-TOF-MS) analysis sh...

OBJECTIVE To evaluate the in vitro and in vivo therapeutic activity of ibuprofen against dermatophytes. METHODS The period of study ranged from June to September 2008. For in vitro investigation of ibuprofen activity, measurement of colony diameter, and dry weight were employed against 4 isolated strains of dermatophytes from 46 patients (30-43 years) suffering from dermatophytoses at Morgan ...

 Abstract Background: Postendodontic pain (PEP) has always been a major problem for patients and dentists and NSAIDs are being used to relieve PEP and it is supposed that some benzodiazepines may potentiate facilitate the analgesic effects of the NSAIDs. This study was conducted to evaluate the effect of alprazolam on the analgesic effect of ibuprofen in PEP treatment. Methods: This randomi...

BACKGROUND Recent warnings from Health Canada regarding codeine for children have led to increased use of nonsteroidal anti-inflammatory drugs and morphine for common injuries such as fractures. Our objective was to determine whether morphine administered orally has superior efficacy to ibuprofen in fracture-related pain. METHODS We used a parallel group, randomized, blinded superiority desig...

BACKGROUND Postendodontic pain (PEP) has always been a major problem for patients and dentists and NSAIDs are being used to relieve PEP and it is supposed that some benzodiazepines may potentiate facilitate the analgesic effects of the NSAIDs. This study was conducted to evaluate the effect of alprazolam on the analgesic effect of ibuprofen in PEP treatment. METHODS This randomized double-bli...

Evidence A meta-analysis and recent randomized controlled trial provide some guidance. • Meta-analysis of 10 trials (N = 1078) of ibuprofen (5 to 10 mg/kg) versus acetaminophen (10 to 15 mg/kg)1: -ibuprofen was superior at 2, 4, and 6 hours; and -at 4 to 6 hours, approximately 15% more ibuprofen patients had fever reduction (number needed to treat = 7). • PITCH randomized controlled trial (N = ...

Ibuprofen has been reported to possess anticancer activity. In the present work, four ibuprofen conjugates of resorcinarene-Polyamidoamine PAMAM-dendrimers were synthesized with eight or 16 ibuprofen moieties. The ibuprofen was released from the dendrimers in a dependent manner. The drug-conjugated nanoresorcinarene-dendrimers showed higher cellular uptake than free ibuprofen. In vitro cytotoxi...