Background: Previous studies demonstrated clusters of cases of IDDM occurring 24 to 48 months after immunization with the hemophilus, pertussis and combined measles mumps rubella vaccines. Data was analyzed to determine if similar clustering of cases of IDDM occurred after immunization with the hepatitis B vaccine. Methods: Data on the incidence of IDDM from hepatitis B immunized and unimmunize...

IDDM is one of the most common chronic disorders of childhood (see Chapter 3). Standardized descriptive studies of the epidemiology of IDDM are being conducted around the world, providing much needed information regarding the frequency and potential risk factors for IDDM in developed and developing countries. In many areas, these investigations are being facilitated through the World Health Org...

Cataracts are uncommon among children with insulin-dependent diabetes mellitus (IDDM); nonetheless, they could result in significant morbidity and a decrease in the life quality of these children. Duration of diabetes and metabolic control over the disease are important contributing factors in the development and advancement of cataract among diabetic pediatric patients. Ophthalmological examin...

OBJECTIVE To follow proinsulin immunoreactive material (PIM) in healthy siblings from the time of diagnosis of insulin-dependent diabetes mellitus (IDDM) in the proband, for at least 2 years. DESIGN AND METHODS The study comprised 148 siblings representing 112 families. The siblings were recruited from the nationwide 'Childhood Diabetes in Finland' study and tested for immunological markers. ...

The smaller form of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD65) is a major autoantigen in two human diseases that affect its principal sites of expression. Thus, destruction of pancreatic beta cells, which results in insulin-dependent diabetes mellitus (IDDM), and impairment of GABA-ergic synaptic transmission in Stiff-Man syndrome (SMS) are both characterized by circulatin...

OBJECTIVE To examine the influence of diabetes on the employment patterns of parents of children living with diabetes. STUDY DESIGN A case-control study of 197 families with an IDDM child and 142 control families without IDDM children was conducted. Case families were identified from a population-based diabetes registry. Brothers and sisters of the parents in the IDDM families were asked to p...

Both IDDM and autoimmune thyroid disease (AITD; Graves' disease or Hashimoto's thyroiditis) are believed to develop through a T-cell-mediated autoimmune process, and genetic factors clearly play an important role in this process. To date, studies have shown that the development of IDDM is controlled by multiple susceptibility genes, including HLA class II genes (IDDM1) and a variable number of ...

OBJECTIVE The hemophilus vaccine has been linked to the development of autoimmune type 1 diabetes, insulin dependent diabetes (IDDM) in ecological studies. METHODS We attempted to determine if the Hemophilus influenza B (HiB) vaccine was associated with an increased risk of IDDM by looking for clusters of cases of IDDM using data from a large clinical trial. All children born in Finland betwe...

The immune response to intradermal or intramuscular hepatitis B vaccine in 18 children with insulin dependent diabetes mellitus (IDDM) compared with 24 healthy children was studied. Patients were divided into responders, hyporesponders, and non-responders according to their antihepatitis B serum concentrations after hepatitis B vaccination. We also studied HLA class II antigen distribution and ...

We investigated the presence of autoantibodies to baculovirus-expressed human recombinant 65- and 67-kD isoforms of glutamate decarboxylase (GAD65 and GAD67) in insulin-dependent diabetes mellitus (IDDM). In the immunoprecipitation test using [35S]methionine-labeled GADs antibodies to GAD65 were detected in 13/15 (87%) islet cell antibody (ICA)-positive and in 1/35 (2.9%) ICA-negative first-deg...