OBJECTIVE To report for the first time a case of reversible minimal change nephrotic syndrome with immunoglobulin A (IgA) deposition associated with heroin. CLINICAL PRESENTATION AND INTERVENTION A 29-year-old male heroin abuser who developed nephrotic syndrome was admitted to our clinic. Renal biopsy revealed minimal change disease with IgA deposition. Because spontaneous complete remission ...

Background. Nephrotic syndrome is caused by a variety of glomerulopathy. The current study investigated the renal histopathological spectrum of patients with nephrotic syndrome who received a renal biopsy in our department within the last 15 years. Methods. One thousand five hundred and twenty-three consecutive patients ( 14 years old at renal biopsy) with nephrotic syndrome were recruited. Pat...

Minimal change disease (MCD) accounts for 10-15% of primary nephrotic syndrome cases in adults [1]. Most cases are idiopathic. However, approximately 10% may have an identifiable cause. Secondary causes may include drugs, toxins, infections and tumours [2]. Non-steroidal anti-inflammatory drugs (NSAIDs) mercury, lithium and bee stings are some established causes of MCD. Although some plant prod...

BACKGROUND Nephrotic syndrome is caused by a variety of glomerulopathy. The current study investigated the renal histopathological spectrum of patients with nephrotic syndrome who received a renal biopsy in our department within the last 15 years. METHODS One thousand five hundred and twenty-three consecutive patients (≥14 years old at renal biopsy) with nephrotic syndrome were recruited. Pat...

Minimal change nephropathy (MCN) is a major cause of nephrotic syndrome in both children and adults. It is characterised by normal appearing glomeruli by light microscopy and the absence of immunoglobulin deposits by immunoflorescence microscopy. On electron microscopy there is diffuse fusion of the epithelial foot processes. MCN is suggested to be caused by a T-cell or B-cell dysfunction and/o...

Idiopathic nephrotic syndrome is the most frequent glomerular disease in children. The mechanisms underlying its pathophysiology have been investigated by genetic, cellular and molecular approaches. While genetic analyses have provided new insights into disease pathogenesis through the discovery of several podocyte genes mutated in distinct forms of inherited nephrotic syndrome, the molecular b...

Address for Correspondence:Kiyoshi Hayasaka, Department of Pediatrics, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan We present two patients with idiopathic nephrotic syndrome who showed temporary indirect hyperbilirubinemia during the course of treatment with immunosuppressant drugs and/or steroids. We analyzed the gene of the bilirubin uridine-diphosphate ...

Minimal change nephropathy (MCN) is the dominant cause of idiopathic nephrotic syndrome in childhood and accounts for 25% of cases of adult nephrotic syndrome [1]. Each new episode of nephrotic syndrome adversely affects quality of life and is associated with complications including infection, thromboembolism and urinary loss of binding transport proteins. Proteinuria usually remits with high d...