All mice harboring the X-linked Gata1low mutation in a predominantly CD1 background are born anemic and thrombocytopenic. They recover from anemia at 1 month of age but remain thrombocytopenic all their life and develop myelofibrosis, a syndrome similar to human idiopathic myelofibrosis, at 12 months. The effects of the genetic background on the myelofibrosis developed by Gata1low mice was asse...

Patients with chronic myelofibrosis often suffer from osteosclerosis, which is associated bone pain and may lead to marrow failure. The pathogenesis of linked aberrant megakaryocyte development function. Null loss-of-function mutations in MPIG6B, codes for the inhibitory heparan sulfate receptor G6b-B, result severe macrothrombocytopenia, large clusters, focal primary mice humans. We investigat...

background: the purpose of this study was to investigate of radiographic pattern and relative frequency of idiopathic osteosclerosis (io) and condensing osteitis (co) in panoramic radiographs. materials and methods: totally 411 panoramic radiographies were randomly selected from patients referred to radiology department of faculty of dentistry, tabriz university of medical sciences. descriptive...

hyperparathyroidism is an endocrine abnormality that frequently causes diffuse osteopenia in the bones. osteosclerosis is a rare phenomenon in adults with primary hyperparathyroidism since the usual skeletal manifestation is generalized osteopenia. we describe a patient with generalized osteosclerosis in the jaws and skull in association with primary hyperparathyroidism, while the other skeleta...

Objective: The aim of this study was to assess the correlation carotid artery calcifications (CACs) and pulp stones with idiopathic osteosclerosis (IO) using digital panoramic radiographs (DPRs) determine whether or IO might be possible indicators presence CACs.Methods: In total, DPRs 1207 patients (645 females 562 males) taken within 2018 were retrospectively evaluated prevalence CACs, accordi...

Purpose: Demonstrate the possible manifestations of SAPHO syndrome. Material and methods: 38-year-old woman with suspected syndrome were performed scintigraphy SPECT/CT for evaluate localization abundance process. Results: Osteosclerosis hyperostosis left clavicle, osteosclerosis L1 vertebra other, less pronounced changes, accompanied by active accumulation 99mTc-MDP, revealed. Conclusion: It i...