Abstract IFN-induced protein with tetratricopeptide repeats (IFITs), known as canonical IFN-stimulated genes (ISGs), play critical roles in regulating immune responses against pathogens and maintaining homeostasis. How the IFIT5 regulates innate is rarely reported remains enigmatic. In this study, we discover that human (hIFIT5) functions a negative regulator of type I IFN (IFN) pathway HEK293T...

background: hepatitis c is a global health problem. the exact mechanisms by which hepatitis c virus (hcv) can evade the host immune system have become controversial. whether hcv polyproteins modulate ifn signalling pathways or hcv proteins are responsible for such a property is the subject of interest. therefore, an efficient baculovirus delivery system was developed to introduce the whole geno...

The administration of interferon has improved the antiviral and immunomodulatory abilities piglets, which is conductive to prevention potential diseases or delay appearance clinical symptoms. This study aimed evaluate effects from recombinant interferon-alpha (IFN-α) on daily care piglets. results were compared a Chinese herbal drug that was shown increase serum levels. In addition, routes oral...

toxoplasmosis is a protozoal infection caused by toxoplasma gondii. toxoplasmosis produce severe damage in patients who are immunosuppresed. in those who are immunosupressed, latent infection can be reactivated resulting in acute disseminating disease. betamethasone is a synthetic glycocorticoid, used as an anti-inflamatory and immunosuppressant in a wide variety of disorders.the aim of this st...

interferon (ifn)-based therapy, the cornerstone for treatment of hepatitis c virus (hcv) infection, is generally considered to be the single most effective treatment strategy for this infection. although most adverse effects of ifn therapy respond very well to the cessation of this drug, there are reports of serious irreversible adverse effects. this review article evaluates the adverse effects...

Oncolytic virotherapy represents a new approach in the treatment of metastatic melanoma. The efficacy this therapeutic is limited by release type I IFNs tumor microenvironment that can induce an antiviral state cells. Here we investigated ability to impair oncolytic virolysis panel human melanoma cell lines. We found cells with dedifferentiated phenotype showed increased IFN mediated resistance...

background: interferon gamma (ifn-γ), a cytokine produced by a variety of cells is involved in the immune response against m. tuberculosis. it activates the production of other cytokines and molecules that kill mycobacterium. ifn-γ also has diagnostic role in identification of active and latent tuberculosis. objective: to determine the level of ifn-γ in the blood of tb patients. methods: ninety...

Abstract Background While interferon-lambdas (IFN-λs) were initially discovered for their role in antiviral immunity at mucosal barriers such as the lung and gut, there are many unanswered questions how IFN-λs uniquely dampen inflammatory immune responses. In mouse colitis models, shown to play a significant promoting epithelial barrier integrity healing. Microbes present gut naturally induce I...