Our previous study reported that the change in the ratio of interleukin (IL)-6 to IL-10 influences the severity of sepsis in patients with systemic inflammatory response syndrome. We evaluated the change in the ratio of IL-6 to IL-10 after administration of ketamine or propofol in endotoxin-exposed rats in order to evaluate the relationship of pro-inflammatory and anti-inflammatory cytokines fo...

We tested whether a decrease in the ratio of interleukin-10 (IL-10) to tumor necrosis factor-alpha (TNF-alpha) correlates with the decrease in cardiac function in heart failure. It has been suggested that TNF-alpha plays a role in the progression of heart failure, and the effect of TNF-alpha in many tissues is modulated by IL-10. Any relation of these two cytokines to heart failure has never be...

BACKGROUND Studies suggested that interleukin-18 (IL-18)/interleukin-10 (IL-10) ratio is an independent predictor of adverse cardiovascular events in patients with acute coronary syndromes (ACS). In this study we aimed to evaluate the predictive significance of IL-18/IL-10 for the occurrence of ACS in patients with stable angina pectoris (SAP) over a 40-month follow-up. METHODS The IL-18, IL-...

The induction of IL-12 and IL-10 production by the immunomodulatory C3 binding glycoprotein (C3bgp) was studied on human peripheral blood mononuclear cells (PBMC). Isolated PBMC from healthy human donors were cultured 24 hours with C3bgp isolated from Cuscuta europea. We studied also the influence of C3bgp on the cytokine production in LPS-, PHAand PWM-stimulated PBMC. The levels of these cytok...