From January 1996 to May 1999, Project ICARE (Intensive Care Antimicrobial Resistance Epidemiology) received 448 nonduplicate clinical isolates of Enterobacteriaceae and Pseudomonas aeruginosa that were reported to be imipenem intermediate or resistant. However, broth microdilution (BMD) confirmatory testing at the Project ICARE central laboratory confirmed this result in only 11 of 123 (8.9%) ...

background and objectives: pseudomonas aeruginosa is one of the most important causative agents of nosocomial infections especially in icu and burn units. p. aeruginosa infections are normally difficult to eradicate due to acquired resistance to many antibiotics. recent appearance of carbapenem resistant p. aeruginosa isolates is considered a major healthcare problem. the present study was cond...

BACKGROUND Recent analyses of hospital outbreaks have documented the spread of resistance to imipenem, which is currently a major problem among gram positive and gram-negative bacteria. The aim of this study was to describe the rate of gram-positive and gram-negative isolates resistance to imipenem as an antibiotic. METHODS Recorded files of 242 hospitalized patients with at least one sample ...

OBJECTIVES To determine the distribution and heterogeneity of metallo-beta-lactamases (MBLs) responsible for imipenem resistance in Chryseobacterium meningosepticum. METHODS Clinical C. meningosepticum isolates (n = 170) were collected from hospitals in Hangzhou, China. Production of MBLs was investigated by determination of imipenem MICs, and by using both a three-dimensional test and a 2-me...

background treatment of infectious diseases is becoming more challenging with each passing year. this is especially true for infections caused by pseudomonas aeruginosa, an opportunistic pathogen with the ability to rapidly develop resistance to multiple classes of antibiotics. objectives this study was conducted to determine the prevalence of metallo-β-lactamase (mbl)–producing strains among m...

OBJECTIVES Successful therapy of carbapenem-resistant Acinetobacter baumannii strains has been reported with colistin, but recently we argued against its use as monotherapy because of the poor results obtained in a mouse pneumonia model. Our aim was to identify antibiotic combinations that were valid therapeutic alternatives in the same model. METHODS We used two carbapenem-resistant A. bauma...

Sir Hospital-acquired infections in critically ill patients remain one of the most important contributors to morbidity and mortality. Hospital-acquired A. baumannii has emerged as a serious threat to ICU patient population. The main purpose of our study was to determine the incidence of ICU acquired imipenem-resistant A. baumannii and its impact on ICU mortality. This prospective study was carr...

conclusions: in the present study, we have figured out that a number of the important anaerobic infections treatment antibiotics have lost partly or totally their effectiveness on b. fragilis. background: bacteroides fragilis are among the most important anaerobic bacteria behind most of the anaerobic infections. they have acquired resistance to essential treatment antibiotics of anaerobic infe...

The mechanisms responsible for reduced susceptibility to imipenem (MIC 2-16 mg/L) were investigated in eight strains of Bacteroides fragilis. All the strains produced elevated levels of beta-lactamase. Four B. fragilis strains produced metallo-beta-lactamase capable of marked imipenem hydrolysis, and these enzymes were shown to be responsible for resistance. There was evidence, from testing sus...