The effect of acute oral treatment of losartan potassium, an angiotensin AT1 receptor blocker, on immobility in the forced swim test have been studied using rifampicin-treated (cytochrome P-450 enzyme-induced) and fluconazole-treated (cytochrome P-450 enzyme-inhibited) swiss albino mice respectively. In vehicle-treated group, an enhancement in immobility time was observed at 3 h and 6 h after l...

The tail suspension test (TST) is widely recognized as a useful experimental paradigm for assessing antidepressant activity and depression-like behavior. We have previously identified ubiquitin-specific peptidase 46 (Usp46) as a quantitative trait gene responsible for decreasing immobility time in the TST in mice. This Usp46 mutation has a 3-bp deletion coding for lysine in the open reading fra...

depression is a heterogenous, multifaceted disorder with symptoms manifested at the psychological, behavioral and physiological level. therefore, present study was designed as a model to analyze the long lasting effects of methylmercury chloride in male rats with a focus on depression like behavior. male albino rats of wistar strain were exposed orally to a dose of 2 mg/kg of methylmercury chlo...

In the present study, we have investigated the effects of silymarine on depression and the possible role of serotonergic system in these effects. The rats were anesthetized intraperitoneally with ketamine hydrochloride and placed in a Stoelting stereotaxic instrument. A stainless steel guide cannula (22-gauge) was implanted in the third ventricular region. The third ventricular region was infus...

Immobility time of rats in the forced swim test was reduced after bilateral infusion of an 18-mer antisense phosphorothioate oligodeoxynucleotide targeted to the glucocorticoid receptor mRNA into the dentate gyrus of the hippocampus. Vehicle-, sense- and scrambled sequence-treated animals spent significantly more time immobile than antisense-treated animals during the initial test. Immunolabeli...

OBJECTIVE To evaluate the behavioral effect of pyridoxine on the antidepressant action of imipramine. METHODS Male Wistar albino mice of weights 25-35gms were used. Two experiments were carried out; the first on the acute effect of pyridoxine on the duration of immobility, and the second on the sub-chronic effects of pyridoxine alone and in combination with imipramine. In the first experiment...