The immunologic phenotypes of 78 diffuse large cell lymphomas were determined by an immunoperoxidase technique using a panel of monoclonal antibodies. The phenotypes were correlated with clinical and morphological parameters by univariate and multivariate analysis. Forty-one lymphomas (53%) expressed immunoglobulin (Ig+). Of the 37 cases that did not express immunoglobulin (Ig-), 9 expressed T ...

ABSTRACT Intrathecal immunoglobulin synthesis is part of the immune response in the central nervous system (CNS). In this study we demonstrate that age, the features of the biological agent, and epidemiological factors modulate the pattern of intrathecal immunoglobulin (Ig) synthesis. We also describe the pattern of intrathecal Ig in patients suffering from bacteria, virus, or parasites induced...

The coexistence of a high IgE level and transient hypogammaglobulinemia infancy ( THI ) with atopic dermatitis (AD) is well known, but the marked serum ≥ 1000 IU/mL rare finding. Literature scarce regarding levels in patients AD after treatment immunoglobulin (Ig). We reported female infant 8 months old, severe AD. She was treated intravenous (IVIG) infusion failure conventional therapy. Initia...

Immunoglobulin (Ig) class switch recombination (CSR) is the process occurring in mature B cells that diversifies effector component of antibody responses. CSR initiated by activity cell-specific enzyme activation-induced cytidine deaminase (AID), which leads to formation programmed DNA double-strand breaks (DSBs) at Ig heavy chain (Igh) locus. Mature use a multilayered and complex regula...

introduction: toxoplasmosis is a parasitic infection cause by toxoplasma gondii. this parasite is associated with congenital infection and can cause abortion, encephalitis or systemic infection in immune- compromised patients. case presentation in this study, two cases of central nervous system toxoplasmosis in leukemia patients are reported. the first case was a 15-year-old girl with acute lym...

The proportion of peripheral blood lymphocytes with cell surface b5 immunoglobulin (Ig) was compared with serum b5 Ig levels in allotype-suppressed and recovering b5 homozygous rabbits in order to establish the cellular defect in suppression and to determine the relation between lymphocyte membrane Ig and secreted Ig of the same allotype. In rabbits fully suppressed for b5, the absence of circu...

General structural features of human Ig proteins are reviewed. The basic four-chain polypeptide structure is described with particular emphasis on IgG as a model for all Ig classes. The dual biologic role of antibody with antigen-binding and the Fc-associated class-specific effector functions is discussed. Certain aspects of Ig structure are highlighted in order to facilitate understanding of s...