PURPOSE To investigate the relationship between immunoglobulin G (IgG)4-related disease (IgG4-RD) and thyroid eye disease (TED) with respect to IgG levels. PATIENTS AND METHODS A retrospective review of total IgG, IgG subclass, and thyroid stimulating immunoglobulin (TSI) levels in 24 patients with TED. RESULTS Five patients (20.8%) demonstrated serum IgG4 levels consistent with IgG4-RD wit...

Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic L17E trimer [FcB(L17E)3] was designed for immunoglobulin G (IgG) delivery into cells. Particle-like liquid droplets were generated by mixing Alexa Fluor 488 labeled IgG (Alexa488-IgG) FcB(L17E)3. Droplet contact the cellular membrane led to spontaneous influx and distribution of Alexa488-IgG throughout cells in seru...

Levels of rotavirus-specific immunoglobulin G (IgG), IgA, IgM, and secretory immunoglobulin in maternal and cord serum, colostrum and milk, and infants' stools were measured by enzyme-linked immunosorbent assay in 92 mothers and their infants. Although antirotaviral IgG, IgA, and secretory immunoglobulin were present in most maternal sera, only IgG crossed the placenta. All samples of colostrum...

Synovial fluid cryoproteins from various inflammatory and noninflammatory arthritides were examined for the presence of immunoglobulin, fibrinogen, antiglobulin activity, and third component of complement and correlated with the synovial fluid leucocyte count. The majority of rheumatoid synovial fluid cryoproteins contained either IgG-IgM complexes or IgG alone. Contrary to previous reports, ma...

UNLABELLED Pemphigus are autoimmune intraepidermal blistering diseases in which immunoglobulin G (IgG) autoantibodies are directed against desmosomal glycoproteins. The aim of this study was to determine the IgG subclass profile of endemic pemphigus foliaceus (fogo selvagem) and pemphigus vulgaris utilizing indirect immunofluorescence. PATIENTS AND METHODS Twenty-five patients with pemphigus ...

Protein A-bearing formalinized heat-inactivated Staphylococcus aureus bind rabbit 125I-IgG with high capacity of IgG for antigen. The affinity of immobilized IgG for antigen is equal to the affinity of soluble antibody, and the capacity for antigen approximates the capacity of soluble antibody for antigen. 125I-IgG bound to high affinity sites on bacteria is not substantially displaced in the p...

Objective: To explore the interference of monoclonal immunoglobulin (M protein) on detection serum LDL-C in patients with multiple myeloma, improve understanding this matter, determine and establish correct method, provide more accurate clinical results through case. Methods: A case was selected for analysis by direct method. Results: The IgG?-type M protein could not be completely eliminated e...

background: the infection in the neonatal period is a significant cause of mortality in the preterm neonates. the transfer of the immunoglobulin from mother to fetus occurs mainly after 32 to 34 weeks of gestation. therefore, preterm neonates are relatively immune compromised. the aim of the study was to evaluate the impact of intravenous immunoglobulin on mortality rates reduction in preterm n...

The review of non-cystic fibrosis bronchiectasis by Smith elegantly highlights the lack of evidence available in some areas. In particular, approach to immunological testing is varied. Table 2 on page 134 in this review describes the diagnostic features required for immunodeficiency (including immunoglobulin G [IgG] subclass 2 deficiency amongst other IgG subclass deficiencies). However, IgG su...

Immunoglobulin A (IgA) was demonstrated in equine serum and secretions. This immunoglobulin had a molecular weight extending from 150,000 to 700,000 and reacted with specific antihuman alpha-chain antiserum. Antigenic determinants specific for secretory IgA were demonstrated and found to be absent on serum IgA. Antigen binding activity was detected in IgA from tears. Purified IgA was antigenica...