The goal of the present paper was to define the immunophenotype of bone marrow mast cells (BMMC) from healthy controls and patients with hematologic malignancies (HM) based on the use of multiple stainings with monoclonal antibodies analyzed by flow cytometry. Our results show that BMMC from both groups of individuals display a similar but heterogeneous immunophenotype. The overall numbers of B...

Uterine lymphoma is a rare disease therefore, information regarding histologic type, immunophenotype of tumor cells and etiologic factors are limited. although secondary involvement of the genital tract occurs in up to 40% of cases• of disseminated lymphoma, lymphoma presenting with primary female genital tract . symptomatology is very unusual. We report a case of B-cell lymphoma in the ut...

Mixed phenotype acute leukemia (MPAL) is an uncommon manifestation of acute leukemia. The aim of this study is to further characterize the genetic landscape of de novo cases of MPAL that fulfill the 2016 World Health Organization (WHO) classification criteria for this entity. We identified 14 cases examined by next generation sequencing (NGS) using 28 (n = 10), 53 (n = 3) or 81 (n = 1) gene pan...

Background: Non-Hodgkin’s lymphoma (NHLs) is known as a heterogeneous group of malignant lymphoproliferative disorders. NHLs are classified into B cell and T cell types. Immunophenotypical assessment of the biopsy specimens can help diagnose NHLs.    Methods: In this study, 77 patients with B cell and T cell lymphoma were selected from Shahid Sadoghi hospital during 2010 to 2...

A panel of commercially available monoclonal antibodies and five heteroantisera were used to distinguish and subtype 138 cases of acute leukemia (AL). The immunophenotype was compared with the French-American-British (FAB) classification obtained on the cases. The immunophenotype discriminated acute myelogenous leukemia (AML) from acute lymphoblastic leukemia (ALL) and recognized cases not dist...

The peripheral blood and bone marrow samples from 50 patients with ALL were investigated by indirect immunofluorescent technique. The most common type of ALL was common-ALL (82%) and the least common was T-ALL (2%). Other subtypes of ALL were unclassified by our technique (8%), B-ALL (4%), and pre B-ALL (4%). The correlation between immunophenotype, clinical condition and hematological pro...