silybum marianum, is known to have anti-inflammatory, hepatoprotective and anticarciogenic effects. the aim of this study was to compare effects of silymarin, rapamycin and fk506 on proliferation and apoptosis of human t cells stimulated with con a. peripheral blood mononuclear cells (pbmc) were stimulated with concavalin a  ( con a) (5µg/ml) and then treated with different inhibitors (silymari...

Immunosuppressive drugs are now unavoidibly used after the transpantation of liver,heart and bone marrow, as well as in certain autoimmune diseases.among these agents,cyclosporine-A (CYA) is one of the most effective Immunosuppressants which is widely used.but as any Immunosuppressive agent,the use of CYA is not without harmful side effects.neurotoxin,nephrotoxic and hepatotoxic complications,m...

balb/c mice are highly susceptible to infection with the protozoan parasite leishmania major. this susceptibility has been attributed in part to the expansion of th2 cells and production of their cytokines, il-4 and il-10 and down-regulation of th1 cytokine, inf-γ. the inability of susceptible hosts to mount the immune response necessary to activate macrophage and destroy the parasites can be d...

Visna virus inoculation of mice before immunization with unrelated antigens caused suppression of humoral and cell-mediated immune responses. The immunosuppressive effect was dependent on the virus dose and time of administration. The number of "background" antibody-producing spleen cells increased slightly after inoculation of Visna virus. Heat treatment of Visna virus abolished its immunosupp...

background: the pathogenesis of many diseases is correlated to irregularity in vascular endothelial growth factor (vegf) expression. results from several association studies show that variation in the level of vegf expression is related to polymorphic sequences within the vegf gene. additionally, there are many studies showing that some gene polymorphisms significantly influence the pharmacokin...

The Effect of Methylmercury. Tetraethyl Lead. and Sodium Arsenite on the Humoral Immune Response in Mice. BLAKLEY. B. R .. SISODIA. C. S .. AND MUKKUR. T. K. ( 19801. Toxicol. Appl. Pharmacol. 52, 245-254. Male mice were exposed to methylmercury. tetraethyl lead. or sodium arsenite for 3 weeks in the drinking water at three or four con· centrations ranging from 0.5 to 10.0 ppm. The humoral comp...

Immunostimulatory effect of aqueous extract of Leucas aspera was evaluated in cyclophosphamide induced immunosuppressive mice. The results clearly show that the aqueous extract of this plant significantly increase the Neutrophil and DTH activity. The extract also elevates the levels of RBC, WBC and Hemoglobin remarkably in immunosuppressive mice(p<0.05). This indicates that Leucas aspera provok...