balb/c mice are highly susceptible to infection with the protozoan parasite leishmania major. this susceptibility has been attributed in part to the expansion of th2 cells and production of their cytokines, il-4 and il-10 and down-regulation of th1 cytokine, inf-γ. the inability of susceptible hosts to mount the immune response necessary to activate macrophage and destroy the parasites can be d...

background: the pathogenesis of many diseases is correlated to irregularity in vascular endothelial growth factor (vegf) expression. results from several association studies show that variation in the level of vegf expression is related to polymorphic sequences within the vegf gene. additionally, there are many studies showing that some gene polymorphisms significantly influence the pharmacokin...

Aufgrund ihrer Verbreitung und ihrer Akzeptanz stellen Rahmenwerke des IT-Service-Managements (ITSM) wie etwa ITIL vielversprechende Ansatz-punkte für die Verankerung von ökologischen Zielen in IT-Organisationen dar. In diesem Beitrag werden am Beispiel des Incident-Managements die Anforderungen an ein ökologisch erweitertes ITSM abgeleitet und konkrete Erweiterungskonzepte eingeführt. Die Konz...

Gerade im Bereich des Skill-Managements ist man auf eine saubere Datenhaltung angewiesen, wenn es um die zentrale Datenhaltung des Kompetenzkatalogs geht [FBW91]. Dieser „Katalog“ dient oft einer Reihe von Systemen als zentrale Instanz zur Verwaltung der Kompetenzen der Mitarbeiter. Leider sind IT-Systeme im Personalbereich oft historisch gewachsen und damit heterogen. Eine ganzheitliche Betrac...

The benefits of learning managements systems have been documented for more than thirty years. Coupled with the astounding potential of the internet they provided a compelling opportunity for “olde” mainframe and LAN developers to “have another go”. This paper describes how a small group of enthusiasts within The University of Auckland Business School built a computer supported learning system (...

recent scientific evidence indicates that distinct patterns of susceptibility in balb/c mice to leishmania major infection are attributable to the differential expansion of distinct cd4+ t-cell subsets and their cytokines production. production of the th1 cytokine ifn-g is associated with resistance, whereas production of the th2 cytokines il-4 and il-10 are associated with extreme susceptibili...