نتایج جستجو برای: immunotoxicity

تعداد نتایج: 652  

Journal: :iranian journal of pharmaceutical research 0
e zabihi neishabouri zm hassan sn ostad

propoxure (ppx) is a well-known carbamate insecticide, which has been used for several decades in the world and iran in agriculture and public health programs. however, there is no clear investigation toward its immunotoxicity as yet. in this study, we examined the effects of subchronic i.p. exposure of ppx on humoral (pfc & ha) and cellular (dth) responses, and also monitored t-cell subtypes u...

2016
Christina Giannakou Margriet VDZ Park Wim H de Jong Henk van Loveren Rob J Vandebriel Robert E Geertsma

Nanomaterials (NMs) are attractive for biomedical and pharmaceutical applications because of their unique physicochemical and biological properties. A major application area of NMs is drug delivery. Many nanomedicinal products (NMPs) currently on the market or in clinical trials are most often based on liposomal products or polymer conjugates. NMPs can be designed to target specific tissues, eg...

2017
Jean C. Pfau

The study of asbestos immunotoxicity is generally applied toward understanding the mechanisms that lead to its infamous outcomes, mesothelioma and asbestosis, rather than as an outcome itself. However, emerging evidence suggests that asbestos exposure has critical inflammatory and autoimmune effects. Although crystalline silica is broadly accepted as an exposure trigger for systemic autoimmune ...

Journal: :Environmental Health 2013

Journal: :Toxicological Sciences 1997

2013
Nygerma L Dangleben Christine F Skibola Martyn T Smith

Exposure to arsenic (As) is a global public health problem because of its association with various cancers and numerous other pathological effects, and millions of people worldwide are exposed to As on a regular basis. Increasing lines of evidence indicate that As may adversely affect the immune system, but its specific effects on immune function are poorly understood. Therefore, we conducted a...

Journal: :Journal of Immunotoxicology 2009

Journal: :Regulatory toxicology and pharmacology : RTP 2016
Susan Dekkers Agnes G Oomen Eric A J Bleeker Rob J Vandebriel Christian Micheletti Joan Cabellos Gemma Janer Natalia Fuentes Socorro Vázquez-Campos Teresa Borges Maria João Silva Adriele Prina-Mello Dania Movia Fabrice Nesslany Ana R Ribeiro Paulo Emílio Leite Monique Groenewold Flemming R Cassee Adrienne J A M Sips Aart Dijkzeul Tom van Teunenbroek Susan W P Wijnhoven

In the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the long term, new testing strategies adapted to a high number of nanomaterials where many factors can affect their environmental and health impact. In the proposed risk assessment...

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