in this study, doxycycline hyclate release behavior from in situ forming drug delivery systems investigated. these systems based on poly()lactide-co-glycolide)(50:50 dissolved in n-methyl-2-pyrrolidone that were evaluated in different concentrations. these systems are useful for local treatment of periodontal diseases. uv spectroscopy is used to determine drug concentration in release medium. a...

AbstractVarious nanoparticles have been investigated as novel drug delivery systems, including solid lipid nanoparticles (SLNs). Due to their rapid clearance from systemic circulation, nanoparticles do not provide sustained action in most cases. Different strategies have been employed to overcome this problem. In this direction, the present study introduces erodible in-situ forming gel systems ...

AbstractVarious nanoparticles have been investigated as novel drug delivery systems, including solid lipid nanoparticles (SLNs). Due to their rapid clearance from systemic circulation, nanoparticles do not provide sustained action in most cases. Different strategies have been employed to overcome this problem. In this direction, the present study introduces erodible in-situ forming gel systems ...

BACKGROUND Three-dimensional (3D) hydrogel-based stem cell therapies contribute to enhanced therapeutic efficacy in treating diseases, and determining the optimal mechanical strength of the hydrogel in vivo is important for therapeutic success. We evaluated the proliferation of human neural stem cells incorporated within in situ-forming hydrogels and compared the effect of hydrogels with differ...

Polymeric hydrogel is a promising class of drug delivery systems with the controlled release behavior in the body. In-situ forming hydrogels can be injected into the body as a fluid which forms a gel within the body tissue and improve the efficacy of the drugs. Various polymers have been used as in-situ hydrogel formulations. These polymeric formulations can form gels at body temperature while ...

We have developed an in-plane bi-polymer check-valve for controlling microfluidic flow and preventing contamination between solutions by tilizing the elastic force of a swollen hydrogel. The valve was created using microfluidic tectonics, a fabrication procedure that allows construction f microscale components and autonomous systems using liquid-phase photopolymerization and in situ fabrication...

An in situ heparin-based forming hydrogel that cures under visible-light is formulated using eosin Y as a photoinitiator with triethanolamine as an electron donor to initiate reaction of thiolated-heparin with acrylate-ended poly(ethylene glycol). Formulations and irradiation conditions are presented for control of heparin content (1.6 to 3.3% w/v), modulus (100-10,000 Pa), and gelation time (3...