background: tumour suppressor genes such as tp53, brca1 and rad51 are involved in dna repair and their malfunctions result in genomic instability and cancer. wild type (wt) tp53 binds to brca1and rad51 in vivo and in vitro. however, mutated tp53 in tumours can interfere with wt tp53 function. we studied how mutation of tp53 in mda-mb-468 cell line could affect its binding capacity and interfere...

Background: Because of the scarcity of antifungal drugs,their undesired side effects and emergence of drug resistant strains research for finding novel antifungal drugs with less side effects is necessary. In this research, the antifungal effects of satureja khuzistanica essence,which is a native plant in our province, on ten kinds of fungi were evaluated. Materials and methods: To extract the...

Background: Radioprotective efficacy of Prunus avium fruit extract (PAE) rich in vitamin A, C, E and anthocyanin was studied against radiation induced biochemical alterations in mice brain. Materials and Methods: In-vitro assays were performed with PAE for its antioxidant studies thereafter for in-vivo study, Swiss albino mice were divided into five groups. Group 1 (control) normal mice. Group ...

Background. To explore the effect of ASMq on proliferation and migration ability of the fibroblast derived from HS of donor (HSFbs) in vitro. Methods. The HSFbs were cultured from tissue specimens and passaged to the 3~4 generation, which were treated with the different concentrations of ASMq and 5-Fu from 1 to 11 days. The difference of HSFbs proliferation activity was analyzed by the CCK-8 me...

Objective(s): Controversial results have been reported regarding the anti-tumor properties of extracellular vesicles derived from mesenchymal stem cells (MSCs). The present study was conducted to evaluate whether secretome derived from Human Wharton’s jelly mesenchymal stem cells (hWJMSCs) may stimulate or inhibit breast cancer growth in vitro and in vivo.<st...

The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and t...