The present investigation was aimed at developing a novel colon targeted system of lornoxicam based on the use of a combination of pH dependent system (to prevent the premature release of drug in the upper GIT) and enzymatically degradation system (to ensure the specificity of drug release in the colon). The drug loaded guar gum microspheres prepared by emulsification cross-linking method were ...

the objective of this work was to develop and evaluate the levofloxacin hemihydrate floating formulations (f1-f9). selection of optimized batch was done by model dependent approach and novel mathematical approach. f1-f9 batches were prepared by direct compression method using gelucire 43/01 (hydrophobic) and hydroxypropylmethylcellulose (hydrophilic) polymer in different ratios. the floating ta...

A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 m m. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed H...

      The objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper GIT, which may result in enhanced absorption and thereby improved bioavailability. The microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (HPMC K 15 M), ethyl cellulo...

to answer challenge of targeted and controlled drug release in oral delivery various materials were studied by different methods. in the present paper, controlled metal based drug (pd(ii) complex) release manner of β‑lactoglobulin (β-lg) nanoparticles was investigated using mathematical drug release model in order to design and production of a new oral drug delivery system for gastrointestinal ...

mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. several synthetic polymers are in use for this purpose. since the biodegradability of the synthetic polymers are questionable, in this investigation, an oral mucoadhesive controlled del...

in order to enhance in vitro dissolution and content uniformity of poorly soluble drug glimepiride by preparing solid dispersions using modified solvent fusion method, solid dispersions of drug were prepared by modified fusion solvent method using peg 6000 and pvp k25 (as carrier). eight batches (f1-f8) were prepared by factorial design (23) by taking three factors i.e. the concentration of: dr...

the objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (ir) and modified release (mr) tablets. the experiment included rats with both normoglyceamia and streptozocin (stz)-induced hyperglyceamia. several mr formulations were designed and in vitro drug release profile was assessed by a dissolution test. for the fur...

the aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, salbutamol sulphate by (water in oil) in oil emulsion technique using ethyl cellulose as the retardant material. various processing and formulation parameters such as drug/polymer ratio, stirring speed, volume of processing medium were optimized to maximize the e...

promethazine hydrochloride, a 5-ht3 antagonist is a powerful antiemetic drug with an oral bioavailability of 25% due to extensive hepatic first pass metabolism and is extremely bitter in taste. to overcome the above draw backs, the present study was carried out to formulate and evaluate fast dissolving taste masked wafers of promethazine hydrochloride for sublingual administration. taste maskin...