Monocyte activation by chemokines is a vital trigger for initiation of atherosclerotic process. Circulating levels of platelet activating factor (PAF), a recognized chemokine, is known to be increased in type 2 diabetes that is linked to accelerated atherosclerosis. To explore the molecular basis we examined the signalling pathways involved in PAF induced monocyte activation. PAF increased migr...

Introduction Chromobox protein homolog 3 (CBX3) has been reported to regulate a variety of cellular biological functions and play an oncogenic role in various tumor. Nevertheless, the CBX3 remains vague ovarian cancer. This research aimed assess potential regulatory mechanism Material methods The expression was determined by qRT-PCR western blotting cancer tissues cell lines. Cell proliferation...

Expression of voltage-gated K(+) (Kv) channel genes is regulated by polyamines in intestinal epithelial cells (IEC-6 line), and Kv channel activity is involved in the regulation of cell migration during early restitution by controlling membrane potential (E(m)) and cytosolic free Ca2+ concentration ([Ca2+](cyt)). This study tests the hypothesis that RhoA of small GTPases is a downstream target ...

Klotho was originally characterized as an aging suppressor gene that predisposed Klotho-deficient mice to premature aging-like syndrome. Although Klotho was recently reported to exhibit tumor suppressive properties during various malignant transformations, the functional role and molecular mechanism of Klotho in hepatocarcinogenesis remains poorly understood. In our present study, immunohistoch...

in iran, the majority of vegetable oil producers , use pet for packaging their products . due to high solubility of pet oligomers in the oils , and shelf life of liquid oils , it is expected that some compounds migrate into the oil . this study was carried out to determine the amount of migration of terephtalates from pet bottles into sunflower oil and the effect of temperature and storage time...

Breast cancer is a kind of malignant tumor that severely threatens women's lives and health worldwide. Tumor-associated macrophages (TAMs) have been reported to mediate progression, while the mechanism still needs further identification. In this study, we found M2 promoted increased cell proliferation migration as well reduced expression interferon regulatory factor 7 (IRF7) miR-1587 in breast ...

Endothelial migration is a crucial aspect of a variety of physiologic and pathologic conditions including atherosclerosis and vascular repair. Reactive oxygen species (ROS) function as second messengers during endothelial migration. Multiple intracellular sources of ROS are regulated by cellular context, external stimulus, and the microenvironment. However, the predominant source of ROS during ...

Introduction Skin scar is a common cutaneous complication, the outcome of which unpleasant. Several microRNAs (miRs) participate in process skin formation. We aimed to explore role miR-27a-3p NIH/3T3 mouse fibroblasts as well downstream protein and signaling cascades. Material methods was aberrantly expressed cells, followed by measurements cell viability, migration expressions proteins related...

We investigated peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands effect on cell motility and the plasminogen activator system using normal MCF-10A and malignant MCF-10CA1 cell lines. Ciglitazone reduced both wound-induced migration and chemotaxis. However, the effect was not reversed with pretreatment of cells with the PPAR-γ-specific antagonist GW9662. Immunoblot analysis of condi...