The validity of the Michaelis-Menten-Briggs-Haldane approximation for single enzyme reactions has recently been improved by the formalism of the total quasi-steady-state approximation. This approach is here extended to fully competitive systems, and a criterion for its validity is provided. We show that it extends the Michaelis-Menten-Briggs-Haldane approximation for such systems for a wide ran...

In December 2003, seventeen years after the first UK research assessment exercise, Italy started up its first-ever national research evaluation, with the aim to evaluate, using the peer review method, the excellence of the national research production. The evaluation involved 20 disciplinary areas, 102 research structures, 18,500 research products and 6,661 peer reviewers (1,465 from abroad); i...

Ameisen: Die heimliche Weltmacht (Ants: Nature's Secret Power) is a nature documentary about ants. Wolfgang Thaler wrote, filmed, and directed the film, which focuses on the work of ant researcher Bert Hölldobler. The 2004 film was produced by Adi Mayer Film for Österreichischer Rundfunk (Austrian Broadcasting), a public service broadcaster headquartered in Vienna, Austria. Ants: Nature's Secre...

Previous work by Tesser (1993) and Bourgeois (2002) found that heritable attitudes are more resistant to social influence and attitude change. The present study sought to replicate and extend previous work by utilizing attitudes and heritability estimates not previously used in studies examining the effect of heritable attitudes on social influence processes. It was hypothesized that attitudesw...

Poverty analysis is often based on national level indicators that are compared over time or across countries. The broad trends that can be identified using aggregate information are useful for evaluating and monitoring the overall performance of a country. For many policy and research applications, however, the information that can be extracted from aggregate indicators is not sufficient. Resea...

This paper examines the out-of-sample performance of various financial variables as predictors of U.S. recessions. Series such as interest rates and spreads, stock prices, and monetary aggregates are evaluated individually and in comparison with other financial and nonfinancial indicators. The analysis focuses on out-of-sample performance from one to eight quarters ahead. Results show that stoc...

In this paper, we investigate competition in banking systems in the EU27 as a whole for the period 2004– 2010, but also for old members’ banking systems compared with new members’ banking systems and for banking systems from countries member of euro zone compares with banking systems from countries non-member of euro zone. In order to investigate this issue, we estimate a non-structural indicat...

Understanding the neural basis of behaviour requires studying brain activity in behaving subjects using complementary techniques that measure neural responses at multiple spatial scales, and developing computational tools for understanding the mapping between these measurements. Here we report the first results of widefield imaging of genetically encoded calcium indicator (GCaMP6f) signals from...

It is widely recognized that citation counts for papers from different fields cannot be directly compared because different scientific fields adopt different citation practices. Citation counts are also strongly biased by paper age since older papers had more time to attract citations. Various procedures aim at suppressing these biases and give rise to new normalized indicators, such as the rel...

We present a modular approach for analyzing calcium imaging recordings of large neuronal ensembles. Our goal is to simultaneously identify the locations of the neurons, demix spatially overlapping components, and denoise and deconvolve the spiking activity from the slow dynamics of the calcium indicator. Our approach relies on a constrained nonnegative matrix factorization that expresses the sp...