previous studies have shown that electrical stimulation (es) increases blood flow, but the exact mechanisms are not clear. the present study was designed to clarify some of the underlying mechanisms involved in this phenomenon. white adult rabbits lt.-6 months old were used. animals were anesthetized by sodium pentobarbital (40 mg/kg, iv) and skin blood flow in the thoracic back was recorded us...

objective(s):berberine, a naturally occurring isoquinoline alkaloid, has shown antitumor properties in some in vitro systems. but the effect of berberine on breast cancer has not yet been completely studied. in this study, we evaluated anticancer properties of berberine in comparison to doxorubicin. materials and methods: the antiproliferative effects of berberine and doxorubicin alone and in c...

Background: Angiotensin converting enzyme (ACE) upregulation in stromal cells of joints affected by rheumatoid arthritis may lead to higher tissue angiotensin II that is a vasoconstrictor and mitogen factor. To date, the role of angiotensin II on regulating blood flow in inflamed joints has not been studied. Methods: Acute and chronic joint inflammation was induced in rabbits by intra-articular...

Objective We have previously shown that Rose Bengal (RB) alone, not as a photosensitiser, could induce apoptotic- and non-apoptotic cell death in different melanoma cell lines. To clarify RB-induced toxicity mechanisms, role of caspases and reactive oxygen specious (ROS) were studied in melanoma cells. Material and Methods Human melanoma cell lines, Me 4405 and Sk-Mel-28 were cultured in DM...

The mechanisms underlying cerebral vasodilatation during hypercapnia are not fully understood. To examine the role of nerves and prostaglandins in the regulation of basal blood flow and in hypercapnia-induced vasodilatation in the cerebral blood vessels of rabbit.Cerebral blood flow was measured by laser Doppler flow-meter in 18 NZW rabbits anesthetized with sodium pentobarbital.  Tetrodetoxin ...

when flow passes over the tube bundles, energy of flow transfers to the tubes. the fluid induced vibrations (fiv) imposed on the tubes is one of the important problems in analyzing the tube bundles and causes several problems. in this work, first, laminar flow around circular cylinder asymmetrically in a channel is simulated. the reynolds number is 20 and 100. the lift forces to tube are not ze...