septicaemia caused by gram-negative pathogens is a dangerous infection which is associated with high incidence of liver dysfunction. the severe and acute hepatotoxicity is presumably due to massive release of endotoxin into systemic circulation after bacterial killing. the direct toxic effect of endotoxin is probably due to the increased production of reactive oxygen intermediates as o 2 - , pe...

AIM To evaluate the tolerability and efficacy of erlotinib treatment in advanced non-small cell lung cancer (NSCLC) patients who had previously experienced severe hepatotoxicity after gefitinib treatment. PATIENTS AND METHODS Twenty-five NSCLC patients with epidermal growth factor receptor (EGFR) mutation were initially treated with gefitinib (250 mg/day). However, 7 of these experienced seve...

Objective. Gefitinib often induces liver damage. A few reports have described that the subsequent administration of erlotinib was associated with less hepatotoxicity, but the safety and efficacy of this treatment are still not fully investigated. Therefore, we evaluated retrospectively the patients with erlotinib following gefitinib-induced hepatotoxicity. Methods and Patients. We retrospective...

BACKGROUND This study was carried out to determine the incidence and predictors of anti-tuberculosis drug induced hepatotoxicity among TB/HIV co-infected patients at Jimma University Hospital, Ethiopia. METHODS/PRINCIPAL FINDINGS A nested case-control study was conducted by reviewing charts of all TB/HIV co-infected patients who commenced anti-TB treatment from January 2008 to December 2011 a...

Oxidizing agents play a major role in the pathogenesis of liver diseases. Pistacia vera (P. vera), contains many antioxidant substances including coenzyme 10, vitamin E and beta-carotene. The current study was designed to evaluate the probable effects of P. vera on carbon tetrachloride (CCl4)-induced hepatotoxicity in male rats. Frothy male Wistar rats were randomly divided into five groups inc...

For the development of novel hepatoprotective agents, C2, C3, C23 and C28 functional groups on asiatic acid were modified, and the prepared compounds were evaluated for their hepatoprotective effects. Among the prepared compounds, 9, 13 and 16 showed significant hepatoprotective activities against CCl4and galactosamine (GaIN)-induced hepatotoxicity. Especially, compound 9 showed the most signif...

flutamide is a non-steroidal antiandrogen commonly used in the treatment of prostate cancer. severe hepatotoxicity occurs in few patients, yet may be fatal. to date, none of the reported cases of flutamide hepatotoxicity has demonstrated thrombocytopenia and chronic liver disease. we report the case of a 55-year-old male with prostatic adenocarcinoma who developed liver failure after six months...

INTRODUCTION The prevalence and risk factors for rifampin, isoniazid and pyrazinamide hepatotoxicity were evaluated in HIV-infected subjects and controls. METHODS Patients with tuberculosis (30 HIV positive and 132 HIV negative), aged between 18 and 80 years-old, admitted to hospital in Brazil, from 2005 to 2007, were selected for this investigation. Three definitions of hepatotoxicity were u...