the culture media optimization is an inevitable part of upstream process development in therapeutic monoclonal antibodies (mabs) production. the quality by design (qbd) approach defines the assured quality of the final product through the development stage. an important step in qbd is determination of the main quality attributes. during the media optimization, some of the main quality attribute...

In this article we consider strategies for exploiting supercomputer technology in solving the sparse matrix problems arising in process simulation and optimization. A new multifrontal solver for use in simulating equilibrium-stage processes and a new parallel frontal solver for large-grained parallel solution of process simulation and optimization problems are described. Results for several pro...

ABB Dynamic Optimization is an extension for the control system 800xA. Exploiting the Aspect Objects technology of 800xA, Dynamic Optimization allows the seamless integration of model based applications, such as model-based process control. Running offline and online using one and the same software environment, Dynamic Optimization provides an attractive framework to apply offline results onlin...

the aim of this study is to find the optimal water pressure and percentage of supply vapour in the feed water heaters (fwhs) of steam power plants, such that they maximize the thermal efficiency of the rankine cycle within pre-specified values of minimum and maximum pressures of the thermodynamic cycle. thermal efficiency is defined as a function of unknown variables (fluid pressure and vapour ...

designing of a pid controller is a very common method for industrial process control and due to its very simple and efficient function; it is used in a wide variety of industrial applications. pid controller to reduce the steady state error and dynamic response of the system is used. pid controller design is an inevitable problem in setting the coefficients need to try a lot of trial and error,...

In this paper, a double-cyclone is used as a gas-solid separator in the fluid bed-drying process to prepare dry HDPE powder from a wet feed of 56000 kg/hr. The quality of dry HDPE depends mainly on particles behavior and flow pattern in the dryer which affect the double-cyclones as an effective equipment in this process. Controlling of the inlet carrier gas causes excellent flow pattern, desire...

in quality control charts, the problem of determining the optimum process mean arises when the deviation of a quality characteristic in one direction is more harmful than in the opposite direction. the failure mode in these two directions is usually different. a great majority of researches in this area have considered asymmet-ric cost function for processes with single quality characteristics....