After a non-inferiority margin is established, a prospective non-inferiority trial is usually conducted to confirm the noninferiority of the new product when compared to the existing product. Non-inferiority trials typically require considerably larger sample sizes than placebo-controlled trials [4]. This is due to the fact that the margin of equivalence (non-inferiority) is often much smaller ...

abstract background: infertility and the reactions of people towards it can lead to psychological disorders which have negative effects on the life of young couples. therefore, this study aims to comparatively analyze the level of mental health, happiness, inferiority feelings, sexual satisfaction and marital conflict in fertile and infertile women in kermanshah. methods: this cross-sectional s...

In Spain, deskilling (bureaucratization): visits perceived as exogenous and prescription perceived as induced. Lack of response capacity. Inferiority complex versus secondary care. Weak leadership in primary care teams. Micromanagement and renewal of the health care team, organizational redesign, good governance and public policy implication with the maximum achievable effectiveness and efficie...

New treatments that are potentially as effective as existing treatments are increasingly being developed, some of which may be preferred because of lower cost, fewer side effects, easier administration or less harm. Non-inferiority trials attempt to establish whether or not a new treatment -- drug or non-drug -- is no worse than an established treatment for which efficacy has been determined in...

BACKGROUND Non-inferiority trials are performed when the main therapeutic effect of the new therapy is expected to be not unacceptably worse than that of the standard therapy, and the new therapy is expected to have advantages over the standard therapy in costs or other (health) consequences. These advantages however are not included in the classic frequentist approach of sample size calculatio...

A BSTRACT : Higher disease rates for blacks (or African Americans) compared to whites are pervasive and persistent over time, with the racial gap in mortality widening in recent years for multiple causes of death. Other racial/ethnic minority populations also have elevated disease risk for some health conditions. This paper considers the complex ways in which race and socioeconomic status (SES)...