UNLABELLED PET with short inhalation of (15)O-O(2) provides regional oxygen extraction fraction (OEF) in a shorter acquisition time and with less radiation exposure than does the steady-state method. The purpose of this study was to test the accuracy of the short-inhalation technique for estimating OEF in healthy human volunteers. METHODS The final study population included 16 healthy volunte...

Clinical observations have shown that some older patients are unable to learn to use a metered dose inhaler (MDI) despite having a normal abbreviated mental test (AMT) score, possibly because of dyspraxia or unrecognised cognitive impairment. Thirty inhaler-naive inpatients (age 76-94) with an AMT score of 8-10 (normal) were studied. Standard MDI training was given and the level of competence r...

In recent years methods in lung diagnostics have been developed using the aerosol bolus inhalation technique (Heyder et al., 1988; Anderson et al., 1989; Schulz et al., 1995; Blanchard 1996). A bolus is a small volume of aerosol sandwiched in particle-free air and inhaled into different volumetric regions of the lung. During inhalation and exhalation the original small bolus is dispersed over a...

Though inhaled medications are mainstay of therapy for COPD patients, assessment and training on rotahaler technique is lacking. Aim of study was to evaluate effect of counseling in inhalation technique of COPD patients focusing on essential items using combination of video and demonstration. 54 patients meeting inclusion criteria were included. On discharge day, baseline assessment of their te...

BACKGROUND Inhalation aids do not require coordination between actuation of a metered dose inhaler (MDI) with inspiration and reduce oropharyngeal impaction. The delivery of salbutamol to the lung and systemic availability following inhalation with three commonly used spacers and an open mouth technique have been evaluated using a simple noninvasive technique based on urinary excretion 30 minut...