This prospective, open-label study was designed to measure the impact of short-term infusion-set disconnects on glucose levels. Continuous subcutaneous insulin infusion therapy allows for uninterrupted delivery of insulin. Patients disconnect their insulin pumps from their infusion sets when showering, swimming, exercising, or during intimate moments. Interrupting insulin infusion results in ce...

Hepatic extraction of insulin was examined in anesthetized dogs before and after constant infusion of insulin (20 and 50 mU/min) with use of samples from the portal vein, mesenteric vein, left common hepatic vein, and the femoral artery. In 19 dogs, measurement of portal vein insulin concentration indicated an overall recovery of 110% of the insulin infused. The range varied from 9 to 303%, ind...

Over the past 10 years there have been many changes in the details of diabetic management. The development of home monitoring for capillary blood glucose and widespread availability of measurements of glycosylated haemoglobin have provided direct evidence that most diabetic children have poor or very poor glycaemic control. Additionally, there has been further evidence in support of the hypothe...

BACKGROUND We retrospectively studied associations between bolus infusion of hydrocortisone and variability of the blood glucose level and changes in insulin rates in intensive care unit (ICU) patients. METHODS 'Glycemic variability' and 'insulin infusion rate variability' were calculated from and expressed as the standard deviation (SD) of all blood glucose levels and insulin infusion rates ...

OBJECTIVE We hypothesized systematic differences in the patterns of programmed basal insulin infusion rates in children and adolescents with type 1 diabetes on continuous subcutaneous insulin infusion (CSII). We aimed at classification of basal insulin infusion rate regimens and comparing patients' underlying clinical characteristics. RESEARCH DESIGN AND METHODS The German/Austrian diabetes d...

OBJECTIVE To compare glycaemic control and insulin dosage in people with type 1 diabetes treated by continuous subcutaneous insulin infusion (insulin infusion pump therapy) or optimised insulin injections. DESIGN Meta-analysis of 12 randomised controlled trials. PARTICIPANTS 301 people with type 1 diabetes allocated to insulin infusion and 299 allocated to insulin injections for between 2.5...

OBJECTIVE Evaluation of the time required until a change in the basal insulin infusion rate with an insulin pump induces subsequent changes in the metabolic effect. RESEARCH DESIGN AND METHODS In this euglycemic glucose clamp study, 10 male subjects with type 1 diabetes received three different subcutaneous insulin infusion rates (0.5, 1.0, and 2.0 units/h; for 4 h each) of insulin lispro (IL) ...

Objective: To compare the efficacy and safety of intravenous Insulin infusion versus subcutaneous in management hyperglycaemia intensive care.
 Study Design: Quasi-experimental study.
 Place Duration Study: Medical Intensive Care Unit Combined Military Hospital Malir, from Jul to Sep 2021.
 Methodology: 68 individuals admitted ICU with blood sugar levels more than 180 mg/dl were ...

Fourteen of the first 15 insulin-dependent diabetics to be treated in our unit by three weeks or more of outpatient continuous subcutaneous insulin infusion with a portable syringe pump completed a questionnaire about their reactions to the system. Motivation was more important to a favourable response than occupation or intelligence. Most patients thought that diabetic control was better with ...