2. Jouanguy E, Altare F, Lamhamedi S, Revy P, Emilie J-F, Levin M, et al. Interferonγ–receptor deficiency in an infant with fatal bacille Calmette-Guérin infection. N Engl J Med. 1996;26:1956–60. 3. Casanova JL, Blanche S, Emile JF, Jouanguy E, Lamhamedi S, Altare S, et al. Idiopathic disseminated bacillus CalmetteGuérin infection: a French national retrospective study. Pediatrics. 1996;98:774–...

The human interferon gamma receptor has previously been assigned to chromosome 6. Chromosome 6 also encodes HLA, the human class I major histocompatibility antigens. However, the presence of chromosome 6 in hamster-human hybrids is by itself insufficient to confer sensitivity to human immune interferon as measured by the induction of human HLA. Human chromosome 21 was found to be the second chr...

conclusions our findings indicate that heterogeneity at +2109 locus of ifn-γ gene but not at +874 locus could interfere with successful therapy in patients infected with hcv genotype 1. results of 158 patients, 110 (69.5%) subjects achieved svr and 48 (30.5%) subjects did not respond to therapy. the frequency of aa genotype (p = 0.001; or: 11.2; ci: 2.26-63.21) and a allele (p = 0.01; or: 3.23;...

background: leishmaniasis is a tropical disease that is endemic in some areas of iran, including east azerbaijan . ifn-γ is one of the cytokines that triggers cell-mediated immunity, thus initiating elimination of the infection. this case-control study was performed to investigate the association between the polymorphism of the ifn-γ gene at the +874a/t locus and visceral leishmaniasis (vl). me...

conclusions here we review the clinical applications, advantages, and limitations of the tuberculin skin test and interferon-gamma release assays and provide an overview of the most recent systematic reviews conducted for the comparison of these tests. context it has been estimated that one-third of the world’s population are suffering from latent tuberculosis infection (ltbi). in order to cont...

tuberculosis pericarditis as a potentially fatal complication of tuberculosis requires effective diagnosis and treatment. we evaluated the efficacy of interferon-gamma (ifn-gamma) and adenosine deaminase (ada) for diagnosing tuberculosis pericarditis in a cohort of iranian patients presenting with pericarditis. we enrolled 38 patients with presentation of pericarditis. all patients underwent di...

Immunization of mice with heat shock protein 60 from Histoplasma capsulatum or a polypeptide from the protein designated F3 confers protection. Vbeta8.1/8.2+ T cells are critically important for the protective efficacy of this antigen. The production of interleukin-10 and gamma interferon following vaccination is essential for efficacy. In this study, we sought to determine whether the absence ...

In this cross-sectional study, we analysed serum concentrations of soluble markers of cellular immune activation, namely, interferon-gamma, neopterin (a product of activated macrophages), soluble interleukin-2 receptor, and soluble CD8, in 25 patients with congestive heart failure. Ten (40%) patients showed increased concentrations (i.e. above the reference ranges of healthy controls) of neopte...

background: cytokines and specially interferon-gamma (ifn-g) are largely responsible for the regulation of the protective im­mune response against mycobacterial infections. several studies have clarified the importance of common variants of ifn- g gene regarding the susceptibility to tuberculosis. bacille calmette-guérin (bcg) vaccine that is used to prevent se­vere forms of tuberculosis could ...