The role of interleukin-1beta (IL-1beta) as a regulator of the immune response, although extensively investigated, is still debated. We then studied the expression of IL-1beta by human dendritic cells (DCs), the professional antigen presenting cells, and its modulation during immune reactions in vitro. Our results show that, on maturation or tetanus toxoid presentation to specific CD4(+) CD40L(...

Interleukin-1beta is up-regulated in the presence of Helicobacter pylori infection. H. pylori infection was associated with E-cadherin methylation. In this study, we examined if IL-1beta could induce promoter methylation of E-cadherin in human gastric cancer cell lines TMK-1, MKN-74 and MKN-7. Cells were treated with IL-1beta (0.025, 0.1, 0.25, 1.0, 2.5 ng/mL) for 6, 12 and 24h. Methylation sta...

It is postulated that stress differentially affects interleukin-1beta (IL-1beta) during ontogenetic life. This study examined the influence of chronic exposure to forced swim (FS) stress or high-light open-field (HL-OF) stress on interleukin-1beta (IL-1beta). The total level of IL-1beta protein was assessed by Western blot analysis of hippocampal extracts. Double immunofluorescence staining was...

The effect of N-acetyl-L-cysteine on interleukin-1beta-induced nitric oxide synthase expression was studied in rat vascular smooth muscle cells to determine if the reduction/oxidation state would modulate cytokine-induced changes. Interleukin-1beta induced the production of nitrite, a stable metabolite of nitric oxide in a time- and dose-dependent manner. Cytokine-induced nitrite production was...

an appropriate differentiation of distinct human cd4+ t cell subset is critical for manipulating these cells for using in immunity related diseases. despite various attempts to clarify the role of different factors involved in th17 differentiation, many crucial contradictions yet remained to be optimized. although it has been shown that the differentiation of in-vitro th17 cells culture conditi...

AIM To examine the role of cytokine interleukin-1beta (IL-1beta) in retinal capillary cell death in diabetes. METHODS The effect of glucose on the expression of IL-1beta was measured in the bovine retinal endothelial cells. The role of IL-1beta in the accelerated endothelial cell loss was determined by investigating the effect of human recombinant IL-1beta on their apoptosis in normal and hig...

The incidence of colorectal cancer in different parts the large intestine is not same, as tumors more often appear distal part colon compared to proximal one. purpose this study was investigate heterogeneity barrier properties and clarify effects Prostaglandin E2 interleukin-1beta on its parts. An in-depth analysis short circuit current, transepithelial electrical resistance paracellular permea...

Background: Doxorubicin is a crucial anticancer medication, however, cardiotoxicity severe adverse effect of doxorubicin therapy. Various mechanisms, including inflammation, have been postulated to account for this negative effect. The omega-7 fatty acid polyunsaturated with anti-inflammatory and antioxidant properties. Therefore, the study's objective was see whethe...