conclusions taken together, pomegranate juice did not affect serum cytokines levels in patients with oa. its role in improving physical function in these patients most likely involves other mechanisms. background osteoarthritis (oa) is the most common musculoskeletal disorder causing disability and loss of function, particularly in the elderly. preclinical and in-vitro studies for mitigation of...

recent studies have established that sex hormones directly or indirectly affect t and b cells and macrophages by manipulating the production of cytokines. in this study the possibility of the effect of 5a-dht on macrophage (mφ) nitric oxide (no) release via interleukin-l, 6 (ll-1β, il-6) or tumor necrosis factor-a (tnfα) was investigated. the endogenous cytokines il-1β, il-6 and tnf-α were neut...

Febrile infection-related epilepsy syndrome (FIRES) characteristically affects previously healthy children, who experience a sudden and explosive onset of super-refractory status epilepticus preceded by febrile infection accompanied fulminant neurogenic inflammation. FIRES, however, can affect individuals all ages is subcategory new-onset refractory epilepticus. This definition FIRES excludes i...

OBJECTIVES This study aimed to assess and compare the levels of interleukin-1beta (IL-1β) and interleukin-6 (IL-6) in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth. MATERIALS AND METHODS This study evaluated 16 dental implants in 8 patients (4 males and 4 females). These patients had at least one healthy implant and one implant with peri-impla...

Recent studies have established that sex hormones directly or indirectly affect T and B cells and macrophages by manipulating the production of cytokines. In this study the possibility of the effect of 5a-DHT on macrophage (MΦ) nitric oxide (NO) release via interleukin-l, 6 (lL-1β, IL-6) or tumor necrosis factor-a (TNFα) was investigated. The endogenous cytokines IL-1β, IL-6 and TNF-α were ...

Objective(s): Inflammation is an immune response toward injuries. Although inflammation is healing response, but in some condition it will lead to chronic disease such as rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, Alzheimer’s and various cancer. Indonesian cassia (Cinnamomum burmanni C. Nees & T. Ness) known to contain coumarin, is widely used for alternative medicine es...

Introduction One of the factors influencing symptoms schizophrenia, which may indicate changes in cognitive functioning patients, is fluctuating level inflammatory cytokines. Objectives The aim review was to analyze available literature on importance selected [interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis α (TNF-α)] schizophrenia and ...

an appropriate differentiation of distinct human cd4+ t cell subset is critical for manipulating these cells for using in immunity related diseases. despite various attempts to clarify the role of different factors involved in th17 differentiation, many crucial contradictions yet remained to be optimized. although it has been shown that the differentiation of in-vitro th17 cells culture conditi...

Interleukin-1beta (IL-1β) is a major cause for induction of various inflammatory mechanisms that are decisively involved to provoke pathogenesis of type 2 diabetes mellitus (T2DM). Interleukin-1 receptor antagonist (IL-1Ra) a naturally occurring anti-inflammatory antagonist of IL-1β has been recently approved for treatment of T2DM but due to its short half-life, higher doses and frequent dosing...

Background: Interleukin-1 receptor antagonist (IL-1Ra) also known as Anakinra is a of IL-1 especially IL-1β. IL-1β increased in infected COVID-19 patient groups. This study aimed that the IL-1Ra contained Conditioned Medium Wharton’s Jelly Mesenchymal Stem Cells (CM-WJMSCs) has potential to inhibit which one cytokine storms occur COVID patients through an in-silico approach. Objective: aims det...