BACKGROUND Malondialdehyde (MDA) is an oxidant that causes damage to membranes, DNA, proteins, and lipids at the cellular level. Antioxidants minimize the effects of oxidants and thus help in formation of healthy granulation tissues with higher level of hydroxyproline and total protein. This study compared the effect of limited access dressing (LAD) with conventional closed dressing biochemica...

Intermittent negative pressure wound therapy with instillation (NPWTi) is starting to be used successfully to treat early periprosthetic infections of endoprostheses. However, few articles have reported the outcome of treatment with intermittent NPWTi for late persistent periprosthetic infections of the hip. In this study, we report two cases who underwent several rounds of radical wound debrid...

COMMUNICATIONSTO THE EDITOR 283 also a box in which the patient was in a sitting position. The pressures used were plus or minus 5 to 9 cm H20.6 Similar physiologic effects have been described as the result of therapy with intermittent positive-pressure breathing (IPPB), whether induced by supra-atmospheric pressure (ie, IPPB apparatus) or by atmospheric pressure induced by the same intratank n...

One of the main clinical features of obstructive sleep apnea is sustained hypertension and elevated sympathetic activity during waking hours. Chronic intermittent hypoxia (CIH), animal model of the hypoxemia associated with obstructive sleep apnea, produces a similar sustained increase in blood pressure. This study determined the role of FosB in the median preoptic nucleus (MnPO) in the sustain...

Background. Correct volume management is essential in patients with respiratory failure. We investigated the ability of respiratory variations in noninvasive pulse pressure (ΔPP), photoplethysmographic waveform amplitude (ΔPOP), and pleth variability index (PVI) to reflect hypovolemia during noninvasive positive pressure ventilation by inducing hypovolemia with progressive lower body negative p...

Tophaceous gout complicated by septic arthritis presents a management dilemma which can often require multiple surgical debridements. There is little published in the literature regarding treatment of these concomitant conditions. We postulate that biofilm may play a role increasing the difficulty of sterilising a tophaceous joint. The use of topical negative pressure therapy that targets biofi...

Three-Dimensional Modeled Custom-made Noninvasive Positive Pressure Ventilation Masks in an Infant Allison Carroll, Israel Amirav, Roger Marchand, Deb Olmstead, Heather Logan, Andrew Grosvenor, Carina Majaesic, Joanna MacLean, and Piush J. Mandhane Division of Pediatric Pulmonology, Department of Mechanical Engineering, and Institute of Reconstructive Sciences in Medicine, University of Alberta...