BACKGROUND Patients with anxiety and depression often have bowel symptoms. Until now, studies investigating a link between altered bowel habit and psychological illness have focused on patients with disturbed defecation presenting to gastroenterologists. AIMS To determine whether patients with anxiety and depression have objective evidence of abnormal intestinal transit irrespective of any bo...

Background/Aims Human gut microbiota harbors numerous metabolic properties essential for the host's health. Increased intestinal transit time affects a part of the population and is notably observed with human aging, which also corresponds to modifications of the gut microbiota. Thus we tested the metabolic and compositional changes of a human gut microbiota induced by an increased transit time...

Cholesterol gallstones are associated with slow intestinal transit in humans as well as in animal models, but the molecular mechanism is unknown. We investigated in C57L/J mice whether the components of a lithogenic diet (LD; 1.0% cholesterol, 0.5% cholic acid and 17% triglycerides), as well as distal intestinal infection with Helicobacter hepaticus, influence small intestinal transit time. By ...

introduction: artemisia dracunculus l. belongs to asteraceae family, and is a medicinal plant widely used in traditional medicine as a remedy for gastrointestinal disturbances. this study was undertaken to evaluate the effects of essential oil of a. dracunculus (eoad) on the rat alimentary tract. methods: the eoad was extracted by clevenger apparatus using hydrodistillation. ld50 was calculated...

BACKGROUND Whilst the use of the mannitol/lactulose test for intestinal permeability has been long established it is not known whether the doses of these sugars modify transit time Similarly it is not known whether substances such as aspirin that are known to increase intestinal permeability to lactulose and mannitol and those such as ascorbic acid which are stated to be beneficial to gastroint...

objective(s) this study was aimed to assess the possible laxative and prokinetic effects of the boiled extract of rosa damascena. materials and methods rats in two groups (n= 7) of test and control were gavaged either with the extract or placebo, respectively. the number, weight and water percentage of feces were studied up to 24 hr. in order to assess the possible osmotic laxative effects of t...

Slowing of intestinal transit by fat is abolished by immunoneutralization of peptide YY (PYY), demonstrating a key role for this gut peptide. How PYY slows intestinal transit is not known. We tested the hypothesis that the slowing of intestinal transit by PYY may depend on an ondansetron-sensitive serotonergic pathway and a naloxone-sensitive opioid pathway. In a fistulated dog model, occluding...

isovanillin and iso-acetovanillon are two phenolic components isolated from a number of plants including pycnocycla spinosa . p. spinosa extract has antispasmodic and antidiarrheal activities. however, no comparative study has been done on antidiarrheal action of isovanillin and iso- acetovanillon, so far. the aim of this study was to investigate antidiarrheal action of isovanillin and iso-acet...