PURPOSE The authors report a case of fungal scleral keratitis and endophthalmitis as a complication of pterygium surgery. METHODS Case presentation. RESULTS A 46-year old woman underwent pterygium excision with topical use of intraoperative mitomycin C. By day 21 after excision, scleral melting was followed by fungal keratitis. Endophthalmitis ensued, which rapidly progressed, despite surgi...

recurrent pterygial cells than on primary ones. Our small prospective interventional study documented favorable outcomes of the use of topical MMC in the management of acutely recurring pterygium. It effectively halted progression and led to regression of the growth, avoiding the need for repeat surgical excision. However, larger clinical trials are warranted to evaluate the long-term safety an...

BACKGROUND The purpose of this study was to investigate the role of intraoperative application of mitomycin C in prevention of glottic restenosis after posterior transverse CO2 laser cordotomy (PTLC) for patients with post-thyroidectomy bilateral vocal fold paralysis. METHODS Twenty-five patients with an impaired airway because of bilateral vocal fold paralysis were treated with PTLC. Patient...

OBJECTIVE To compare the rate of recurrence and complications of pterygium following surgical excision by applying 0.02% mitomycin-C intraoperatively or using topical 0.02 % mitomycin-C drops postoperatively. STUDY DESIGN Randomized clinical trial. PLACE AND DURATION OF STUDY Baqai Medical University Hospital, Department of Ophthalmology, from January 2001 to July 2005. METHODOLOGY Eighty...

Objective Background: 2% to 6% of vasectomized men will ultimately seek vasectomy reversal and late stricture and obstruction after operation are relatively common. Objective: To find a method for improving of vasovasostomy outcomes, we used intra-operative local mitomycin-C to prevent possible fibrosis and stricture. MaterialsAndMethods Design, setting, and participants: 44 patients in our ref...

MMC when applied topically or injected subconjunctivally, prevents proliferation of fibroblasts within the subconjunctival space and tenon’s capsule. It also has a lethal effect on vascular endothelial cells. A single application of MMC can cause localized, irreversible inhibition of both fibroblasts and vascular endothelial cells. MMC is estimated to be 100 times more potent than 5-FU in fibro...

Background: Surgical cytoreduction and simultaneous hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is a common treatment for peritoneal carcinomatosis. During chemotherapy, mitomycin C frequently used. Mitomycin known to be nephrotoxic. Little about the effect of systemically absorbed on renal function during HIPEC surgery. Methods: In twenty-two patients undergoing cytoreduct...

The ability of mitomycin C to inhibit fibroblasts in vitro has prompted its use during standard surgical procedures as a means of preventing the development of adhesions and stenosis. We conducted a prospective study to evaluate the effectiveness of topical mitomycin C in maintaining an open external auditory canal in 6 ears of 4 patients with aural fibrotic atresia who were undergoing meatopla...

purpose: to compare the success rate of mitomycin-c versus bevacizumab for prevention of bleb failure following phacotrabeculectomy. method: in this study 74 eyes of 69 patients with uncontrolled iop, progressive visual field loss and cataract were randomized in two groups. in the first group, after conjunctival peritomy at the sclera flap site, sponge pats soaked in mitomycin c with concentrat...